The correlation between neurodegenerative disease and protein aggregation in the brain
has long been recognized, but a causal relationship has not been unequivocally …

Cerebral amyloid angiopathy of the β‐amyloid type (Aβ‐CAA) is a risk factor for hemorrhagic
stroke and independently is believed to contribute to dementia. Naturally occurring animal …

Several pathogenic Alzheimer's disease (AD) mutations have been described, all of which
cause increased amyloid β-protein (Aβ) levels. Here we present studies of a pathogenic …

Inhibition of the accumulation of amyloid β‐peptide (Aβ) and the formation of β‐amyloid
fibrils (fAβ) from Aβ, as well as the destabilization of preformed fAβ in the central nervous …

Abstract Cerebral deposition of amyloid β-peptide (Aβ) in the brain is an invariant feature of
Alzheimer's disease (AD). A consistent protective effect of wine consumption on AD has …

Aberrant protein aggregation is a common feature of late-onset neurodegenerative
diseases, including Alzheimer's disease, which is associated with the misassembly of the …

Considerable circumstantial evidence suggests that Aβ42 is the initiating molecule in
Alzheimer's disease (AD) pathogenesis. However, the absolute requirement for Aβ42 for …

Over residues 15–36, which comprise the H-bonded core of the amyloid fibrils it forms, the
Alzheimer's disease plaque peptide amyloid β (Aβ) possesses a very similar sequence to …

Numerous studies have established a pivotal role for Aβ42 in Alzheimer's disease (AD)
pathogenesis. In contrast, although Aβ40 is the predominant form of amyloid β (Aβ) …

Real-time monitoring of fibril growth is essential to clarify the mechanism of amyloid fibril
formation. Thioflavin T (ThT) is a reagent known to become strongly fluorescent upon …