In the last century, small-molecule natural products were the main inspiration for most drug
discovery programs based either on high-throughput screening (HTS) or rational design …

Significance: Disulfides are important building blocks in the secondary and tertiary structures
of proteins, serving as inter-and intra-subunit cross links. Disulfides are also the major …

Disulfides are widely found in natural products and find a wide range of applications in life
sciences, materials chemistry and other fields. The preparation of disulfides mainly rely on …

From life science to material science, to pharmaceutical industry, and to food chemistry,
polysulfides are vital structural scaffolds. However, there are limited synthetic methods for …

Polysulfides are significant compounds in life science, pharmaceutical science, and
materials science. Therefore, polysulfide construction is in great demand. The controllable …

Disulfide, as a common structural motif, has been frequently used in pharmaceuticals, nature
products, and chemical biology. This chapter focuses on the methodologies that were …

Disulfide bond formation is a common mechanism for regulating conformational changes in
proteins during oxidative folding. Despite extensive studies of the use of multiple disulfide …

Abstract I. Introduction 38 A. Protein Conformations and Dynamics 38 B. Protein‐Energy
Landscapes: The Folding Problem and Dynamics in the Native State 38 1. Protein …

Radical substitution on tetrasulfides is demonstrated to be a highly effective means to
prepare unsymmetric disulfides. Alkyl and aryl radicals generated thermally or …

This review examines oxidative protein folding within the mammalian endoplasmic reticulum
(ER) from an enzymological perspective. In protein disulfide isomerase-first (PDI-first) …