The endoplasmic reticulum (ER) mediates the first steps of protein assembly within the
secretory pathway and is the site where protein folding and quality control are initiated. The …

Diabetes pathogenic mechanisms and potential new therapies b... : Current Opinion in
Endocrinology, Diabetes and Obesity Diabetes pathogenic mechanisms and potential new …

Abstract Wolfram Syndrome 1 (WFS1) protein is an endoplasmic reticulum (ER) factor
whose deficiency results in juvenile-onset diabetes secondary to cellular dysfunction and …

Macrovascular disease is tightly associated with obesity-induced metabolic syndrome.
Sitagliptin (SIT), an orally stable selective inhibitor of Dipeptidyl peptidase-4 (DPP-4), has …

Mutations in the WFS1 gene, encoding wolframin (WFS1), cause endoplasmic reticulum
(ER) stress and are associated with a rare autosomal-recessive disorder known as Wolfram …

Annual reduction rate of corneal endothelial cell density (ECD) varies among etiologies,
however, the cause of chronic endothelial cell loss is still unknown. We recently reported the …

Highlights•Wolfram syndrome (WS) is a rare, incurable disease caused by mutations in the
WFS1 gene.•Clinical hallmarks of WS include childhood-onset of diabetes mellitus and …

Background and Purpose Quinic acid (QA) is an abundant natural compound from plant
sources which may improve metabolic health. However, little attention has been paid to its …

Sirolimus (rapamycin) is an immunosuppressive drug used in transplantation. One of its
major side effects is the increased risk of diabetes mellitus; however, the exact mechanisms …

Diabetes mellitus is a chronic disease affecting over 500 million adults globally and is
mainly categorized as type 1 diabetes mellitus (T1DM), where pancreatic beta cells are …