[HTML][HTML] CpG 1018® adjuvant enhances Tdap immune responses against Bordetella pertussis in mice
MA DeJong, MA Wolf, GJ Bitzer, JM Hall, E Sen-Kilic… - Vaccine, 2022 - Elsevier
Bordetella pertussis is the causative agent of whooping cough (pertussis), a severe
respiratory disease that can be fatal, particularly in infants. Despite high vaccine coverage …
respiratory disease that can be fatal, particularly in infants. Despite high vaccine coverage …
Intranasal immunization with acellular pertussis vaccines results in long-term immunity to Bordetella pertussis in mice
Bordetella pertussis colonizes the respiratory mucosa of humans, inducing an immune
response seeded in the respiratory tract. An individual, once convalescent, exhibits long …
response seeded in the respiratory tract. An individual, once convalescent, exhibits long …
Induction of protective antiplague immune responses by self-adjuvanting bionanoparticles derived from engineered Yersinia pestis
ABSTRACT A Yersinia pestis mutant synthesizing an adjuvant form of lipid A
(monophosphoryl lipid A, MPLA) displayed increased biogenesis of bacterial outer …
(monophosphoryl lipid A, MPLA) displayed increased biogenesis of bacterial outer …
Intranasal challenge with B. pertussis leads to more severe disease manifestations in mice than aerosol challenge
KL Weaver, GJ Bitzer, MA Wolf, GM Pyles, MA DeJong… - Plos one, 2023 - journals.plos.org
The murine Bordetella pertussis challenge model has been utilized in preclinical research
for decades. Currently, inconsistent methodologies are employed by researchers across the …
for decades. Currently, inconsistent methodologies are employed by researchers across the …
Blockade of the adenylate cyclase toxin synergizes with opsonizing antibodies to protect mice against Bordetella pertussis
AM DiVenere, D Amengor, RP Silva, JA Goldsmith… - Mbio, 2022 - Am Soc Microbiol
Bordetella produces an array of virulence factors, including the adenylate cyclase toxin
(ACT), which is essential, immunogenic in humans, and highly conserved. Despite …
(ACT), which is essential, immunogenic in humans, and highly conserved. Despite …
Evaluation of a novel mRNA-pertussis vaccine against emerging clinical isolates of Bordetella pertussis
GJ Bitzer - 2023 - researchrepository.wvu.edu
Bordetella pertussis is a Gram-negative obligate aerobe that causes a respiratory disease
known as pertussis or whooping cough. Pertussis is most severe in younger children …
known as pertussis or whooping cough. Pertussis is most severe in younger children …