Molecular basis of familial and sporadic Alzheimer's disease

J Dorszewska, M Prendecki… - Current Alzheimer …, 2016 - ingentaconnect.com
Alzheimer's disease (AD) is a multifactorial disease with genetic (70%) and environmental
(30%) causes. Among the genetic factors are genes associated with a family history of the …

Application and mechanisms of triptolide in the treatment of inflammatory diseases—a review

K Yuan, X Li, Q Lu, Q Zhu, H Jiang, T Wang… - Frontiers in …, 2019 - frontiersin.org
Bioactive compounds from medicinal plants with anti-inflammatory and immunosuppressive
effects have been emerging as important sources of drugs for the treatment of inflammatory …

Pharmacological effects of active components of Chinese herbal medicine in the treatment of Alzheimer's disease: a review

ZY Wang, JG Liu, H Li, HM Yang - The American Journal of Chinese …, 2016 - World Scientific
Alzheimer's disease (AD), the most common neurodegenerative disorder associated with
dementia, not only severely decreases the quality of life for its victims, but also brings a …

Triptolide: Medicinal chemistry, chemical biology and clinical progress

W Hou, B Liu, H Xu - European journal of medicinal chemistry, 2019 - Elsevier
In the past decades, triptolide has attracted considerable interests in the organic and
medicinal chemistry society owing to its intriguing structure features and promising multiple …

Natural products as a potential modulator of microglial polarization in neurodegenerative diseases

X Jin, MY Liu, DF Zhang, X Zhong, K Du, P Qian… - Pharmacological …, 2019 - Elsevier
abstract Neurodegenerative diseases (NDs) are characterized by the progressive loss of
structure and function of neurons most common in elderly population, mainly including …

BHBA treatment improves cognitive function by targeting pleiotropic mechanisms in transgenic mouse model of Alzheimer's disease

Y Wu, Y Gong, Y Luan, Y Li, J Liu, Z Yue… - The FASEB …, 2020 - Wiley Online Library
Accumulation of amyloid β (Aβ) peptide, inflammation, and oxidative stress contribute to
Alzheimer's disease (AD) and trigger complex pathogenesis. The ketone body β …

Recent advances in traditional Chinese medicine for kidney disease

Y Zhong, MC Menon, Y Deng, Y Chen, JC He - American Journal of Kidney …, 2015 - Elsevier
Because current treatment options for chronic kidney disease (CKD) are limited, many
patients seek out alternative therapies such as traditional Chinese medicine. However, there …

Research progress of natural products and their derivatives against Alzheimer's disease

JY Liu, HY Guo, ZS Quan, QK Shen… - Journal of enzyme …, 2023 - Taylor & Francis
Abstract Alzheimer's disease (AD), a persistent neurological dysfunction, has an increasing
prevalence with the aging of the world and seriously threatens the health of the elderly …

The role of chronic inflammation in various diseases and anti‐inflammatory therapies containing natural products

RX Wang, M Zhou, HL Ma, YB Qiao, QS Li - ChemMedChem, 2021 - Wiley Online Library
Chronic inflammation represents a long‐term reaction of the body's immune system to
noxious stimuli. Such a sustained inflammatory response sometimes results in lasting …

The therapeutic potential of triptolide and celastrol in neurological diseases

Y Cui, X Jiang, J Feng - Frontiers in Pharmacology, 2022 - frontiersin.org
Neurological diseases are complex diseases affecting the brain and spinal cord, with
numerous etiologies and pathogenesis not yet fully elucidated. Tripterygium wilfordii Hook …