Withania somnifera (L.) Dunal: Phytochemistry, structure-activity relationship, and anticancer potential

D Tewari, V Chander, A Dhyani, S Sahu, P Gupta… - Phytomedicine, 2022 - Elsevier
Background Ayurveda is a highly recognized, well-documented, and well-accepted
traditional medicine system. This system utilizes many natural products in various forms for …

Potential utility of natural products against oxidative stress in animal models of multiple sclerosis

Z Zha, S Liu, Y Liu, C Li, L Wang - Antioxidants, 2022 - mdpi.com
Multiple sclerosis (MS) is an autoimmune-mediated degenerative disease of the central
nervous system (CNS) characterized by immune cell infiltration, demyelination and axonal …

[HTML][HTML] Suppression of TRPV1/TRPM8/P2Y nociceptors by withametelin via downregulating MAPK signaling in mouse model of vincristine-induced neuropathic pain

A Khan, B Shal, AU Khan, R Ullah, MW Baig… - International journal of …, 2021 - mdpi.com
Vincristine (VCR) is a widely used chemotherapy drug that induced peripheral painful
neuropathy. Yet, it still lacks an ideal therapeutic strategy. The transient receptor potential …

Withametelin, a novel phytosterol, alleviates neurological symptoms in EAE mouse model of multiple sclerosis via modulation of Nrf2/HO-1 and TLR4/NF-κB signaling

A Khan, B Shal, AU Khan, T Bibi, S ul Islam… - Neurochemistry …, 2021 - Elsevier
Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disorder of the central
nervous system (CNS) that remains incurable. Withametelin (WMT), a phytosterol, showed …

Wound healing, antioxidant and antibacterial activities of polyphenols of Psidium guajava L. leaves

K Bilal, F Mehboob, N Akhtar, IA Mirza, MK Okla… - South African Journal of …, 2024 - Elsevier
The current study aimed to evaluate the in vivo wound healing potential of Psidium guajava
L. by wound excision model owing to its ethnomedicinal use as a wound healer since olden …

Profiling of antifungal activities and in silico studies of natural polyphenols from some plants

B Khanzada, N Akhtar, MK Okla, SA Alamri… - Molecules, 2021 - mdpi.com
A worldwide increase in the incidence of fungal infections, emergence of new fungal strains,
and antifungal resistance to commercially available antibiotics indicate the need to …

Medicinal Characteristics of Withania somnifera L. in Colorectal Cancer Management

JM Macharia, Z Káposztás, RL Bence - Pharmaceuticals, 2023 - mdpi.com
Research into tumorigenic pathways can aid in the development of more efficient cancer
therapies and provide insight into the physiological regulatory mechanisms employed by …

The genus Datura L.(Solanaceae): a systematic review of botany, traditional use, phytochemistry, pharmacology, and toxicology

W Lian, Y Wang, J Zhang, Y Yan, C Xia, H Gan… - Phytochemistry, 2022 - Elsevier
The genus Datura has been used as an important traditional medicine in China, as well as
in other countries worldwide. This review summarizes the latest progress and perspective of …

Evaluation of analgesic and anti-inflammatory activities and molecular docking analysis of steroidal lactones from Datura stramonium L.

G Chandan, C Kumar, P Chibber, A Kumar, G Singh… - Phytomedicine, 2021 - Elsevier
Background Datura stramonium L. is widely used across the world for its therapeutic
potential to treat inflammatory disorders. The current work was designed to isolate and …

Natural compounds as potential therapeutic candidates for multiple sclerosis: Emerging preclinical evidence

J Yuan, Y Tao, M Wang, F Huang, X Wu - Phytomedicine, 2024 - Elsevier
Background Multiple sclerosis is a chronic neurodegenerative disease, with main
characteristics of pathological inflammation, neural damage and axonal demyelination …