Every cell must solve the problem of how to fold its genome. We describe how the folded
state of chromosomes is the result of the combined activity of multiple conserved …

Structural maintenance of chromosomes (SMC) complexes fold genomes by extruding DNA
loops. In eukaryotes, loop-extruding SMC complexes form topologically associating domains …

Hi-C and 3C-seq are powerful tools to study the 3D genomes of bacteria and archaea,
whose small cell sizes and growth conditions are often intractable to detailed microscopic …