One‐third of the world population is estimated to have Mycobacterium tuberculosis infection.
Accurate and timely identification of infected individuals is critical for treatment and control …

From the early sixteenth and seventeenth centuries to the present day of life, tuberculosis
(TB) still is a global health threat with some new emergence of resistance. This type of …

Accumulating evidence from experimental animal models suggests that antibodies play a
protective role against tuberculosis (TB). However, little is known about the antibodies …

Rationale: Tuberculosis (TB) remains a leading cause of death, and the role of T-cell
responses to control Mycobacterium tuberculosis infections is well recognized. Patients with …

Although post-translational modifications of protein antigens may be important componenets
of some B cell epitopes, the determinants of T cell immunity are generally nonmodified …

Background The detection of latent tuberculosis infection (LTBI) is a major component of
tuberculosis (TB) control strategies. In addition to the tuberculosis skin test (TST), novel …

Background. Changes in the phenotype and function of Mycobacterium tuberculosis (M.
tuberculosis)-specific CD4+ and CD8+ T-cell subsets in response to stage of infection may …

Every day approximately six thousand people die of Tuberculosis (TB). Its causative agent,
Mycobacterium tuberculosis (Mtb), is an ancient pathogen that through its evolution …

Mycobacterium tuberculosis and Mycobacterium bovis bacillus Calmette–Guérin produce a
heparin-binding hemagglutinin adhesin (HBHA) required for extrapulmonary dissemination …

Intracellular cytokine staining combined with flow cytometry is one of a number of assays
designed to assess T-cell immune responses. It has the specific advantage of enabling the …