From the early sixteenth and seventeenth centuries to the present day of life, tuberculosis (TB) still is a global health threat with some new emergence of resistance. This type of …
N Zimmermann, V Thormann, B Hu… - EMBO molecular …, 2016 - embopress.org
Accumulating evidence from experimental animal models suggests that antibodies play a protective role against tuberculosis (TB). However, little is known about the antibodies …
JM Hougardy, S Place, M Hildebrand… - American journal of …, 2007 - atsjournals.org
Rationale: Tuberculosis (TB) remains a leading cause of death, and the role of T-cell responses to control Mycobacterium tuberculosis infections is well recognized. Patients with …
S Temmerman, K Pethe, M Parra, S Alonso… - Nature medicine, 2004 - nature.com
Although post-translational modifications of protein antigens may be important componenets of some B cell epitopes, the determinants of T cell immunity are generally nonmodified …
JM Hougardy, K Schepers, S Place, A Drowart… - PloS one, 2007 - journals.plos.org
Background The detection of latent tuberculosis infection (LTBI) is a major component of tuberculosis (TB) control strategies. In addition to the tuberculosis skin test (TST), novel …
KM Pollock, HS Whitworth… - The Journal of …, 2013 - academic.oup.com
Background. Changes in the phenotype and function of Mycobacterium tuberculosis (M. tuberculosis)-specific CD4+ and CD8+ T-cell subsets in response to stage of infection may …
M Coppola, THM Ottenhoff - Seminars in immunology, 2018 - Elsevier
Every day approximately six thousand people die of Tuberculosis (TB). Its causative agent, Mycobacterium tuberculosis (Mtb), is an ancient pathogen that through its evolution …
K Pethe, P Bifani, H Drobecq… - Proceedings of the …, 2002 - National Acad Sciences
Mycobacterium tuberculosis and Mycobacterium bovis bacillus Calmette–Guérin produce a heparin-binding hemagglutinin adhesin (HBHA) required for extrapulmonary dissemination …
SG Smith, K Smits, SA Joosten, KE van Meijgaarden… - PloS one, 2015 - journals.plos.org
Intracellular cytokine staining combined with flow cytometry is one of a number of assays designed to assess T-cell immune responses. It has the specific advantage of enabling the …