Towards a novel frontier in the use of epigenetic clocks in epidemiology

JJ Martínez-Magaña, J Hurtado-Soriano… - Archives of Medical …, 2024 - Elsevier
Health problems associated with aging are a major public health concern for the future.
Aging is a complex process with wide intervariability among individuals. Therefore, there is a …

Educational mobility, pace of aging, and lifespan among participants in the Framingham heart study

GHJ Graf, AE Aiello, A Caspi, M Kothari, H Liu… - JAMA Network …, 2024 - jamanetwork.com
Importance People who complete more education live longer lives with better health. New
evidence suggests that these benefits operate through a slowed pace of biological aging. If …

[HTML][HTML] Epigenetic Mechanisms in Aging: Extrinsic Factors and Gut Microbiome

A Borrego-Ruiz, JJ Borrego - Genes, 2024 - mdpi.com
Background/Objectives: Aging is a natural physiological process involving biological and
genetic pathways. Growing evidence suggests that alterations in the epigenome during …

Generations of epigenetic clocks and their links to socioeconomic status in the Health and Retirement Study

EM Crimmins, ET Klopack, JK Kim - Epigenomics, 2024 - Taylor & Francis
Aim: This is a brief description of links between nine epigenetic clocks related to human
aging and socioeconomic and behavioral characteristics as well as health outcomes …

Five years of change in adult twins: longitudinal changes of genetic and environmental influence on epigenetic clocks

K Miao, S Liu, W Cao, J Lv, C Yu, T Huang, D Sun… - BMC medicine, 2024 - Springer
Background Epigenetic clocks were known as promising biomarkers of aging, including
original clocks trained by individual CpG sites and principal component (PC) clocks trained …

[HTML][HTML] Epigenetic Aging Helps Explain Differential Resilience in Older Adults

ET Klopack, EM Crimmins - Demography, 2024 - pmc.ncbi.nlm.nih.gov
Past research suggests that resilience to health hazards increases with age, potentially
because less resilient individuals die at earlier ages, leaving behind their more resilient …

Educational Mobility, the Pace of Biological Aging, and Lifespan in the Framingham Heart Study

GH Graf, AE Aiello, A Caspi, M Kothari, H Liu, TE Moffitt… - medRxiv, 2023 - medrxiv.org
Importance People who complete more education live longer lives with better health. New
evidence suggests that these benefits operate through a slowed pace of biological aging. If …

[HTML][HTML] The embodiment of parental death in early life through accelerated epigenetic aging: Implications for understanding how parental death before 18 shapes age …

MP Farina, ET Klopack, D Umberson… - SSM-Population Health, 2024 - Elsevier
Parental death in early life has been linked to various adverse health outcomes in older
adulthood. This study extends prior research to evaluate how parental death in early life is …

GrimAge is elevated in older adults with mild COVID-19 an exploratory analysis

P García-delaTorre, NA Rivero-Segura… - GeroScience, 2024 - Springer
COVID-19 has been contained; however, the side effects associated with its infection
continue to be a challenge for public health, particularly for older adults. On the other hand …

Now and then in eukaryotic DNA methylation

RA Stein, FE Gomaa, P Raparla… - Physiological …, 2024 - journals.physiology.org
Since the mid-1970s, increasingly innovative methods to detect DNA methylation provided
detailed information about its distribution, functions, and dynamics. As a result, new …