Exosomes as therapeutic and drug delivery vehicle for neurodegenerative diseases

Z Nouri, A Barfar, S Perseh, H Motasadizadeh… - Journal of …, 2024 - Springer
Neurodegenerative disorders are complex, progressive, and life-threatening. They cause
mortality and disability for millions of people worldwide. Appropriate treatment for …

The molecular effects of environmental enrichment on Alzheimer's disease

AKY Liew, CH Teo, T Soga - Molecular neurobiology, 2022 - Springer
Environmental enrichment (EE) is an environmental paradigm encompassing sensory,
cognitive, and physical stimulation at a heightened level. Previous studies have reported the …

Mesenchymal stem cell-derived extracellular vesicles protect retina in a mouse model of retinitis pigmentosa by anti-inflammation through miR-146a-Nr4a3 axis

J Zhang, P Li, G Zhao, S He, D Xu, W Jiang… - Stem Cell Research & …, 2022 - Springer
Background Retinitis pigmentosa is a rod-cone degenerative disease that induces
irreversible vision loss. This study probed the protective capacity of mesenchymal stem cell …

Astrocytic MicroRNAs and transcription factors in Alzheimer's disease and therapeutic interventions

A Nassar, T Kodi, S Satarker, P Chowdari Gurram… - Cells, 2022 - mdpi.com
Astrocytes are important for maintaining cholesterol metabolism, glutamate uptake, and
neurotransmission. Indeed, inflammatory processes and neurodegeneration contribute to …

Cognitive dysfunction associated with COVID-19: Prognostic role of circulating biomarkers and microRNAs

M Alvarez, E Trent, BDS Goncalves… - Frontiers in aging …, 2022 - frontiersin.org
COVID-19 is renowned as a multi-organ disease having subacute and long-term effects with
a broad spectrum of clinical manifestations. The evolving scientific and clinical evidence …

Investigating the impact of environmental enrichment on proteome and neurotransmitter‐related profiles in an animal model of Alzheimer's disease

Y Nam, S Kim, YH Park, BH Kim, SJ Shin, SH Leem… - Aging …, 2024 - Wiley Online Library
Alzheimer's disease (AD) is a neurodegenerative disorder associated with behavioral and
cognitive impairments. Unfortunately, the drugs the Food and Drug Administration currently …

The concept of resilience to Alzheimer's Disease: current definitions and cellular and molecular mechanisms

LE de Vries, I Huitinga, HW Kessels, DF Swaab… - Molecular …, 2024 - Springer
Some individuals are able to maintain their cognitive abilities despite the presence of
significant Alzheimer's Disease (AD) neuropathological changes. This discrepancy between …

Environmental enrichment improves cognitive function, learning, memory and anxiety-related behaviours in rodent models of dementia: implications for future study

SNM Sahini, NAMN Hazalin, BN Srikumar… - … of Learning and …, 2024 - Elsevier
Environmental enrichment (EE) is a process of brain stimulation by modifying the
surroundings, for example, by changing the sensory, social, or physical conditions. Rodents …

The complex effects of miR-146a in the pathogenesis of Alzheimer's disease

Y Long, J Liu, Y Wang, H Guo… - Neural Regeneration …, 2025 - journals.lww.com
Alzheimer's disease is a neurodegenerative disorder characterized by cognitive dysfunction
and behavioral abnormalities. Neuroinflammatory plaques formed through the extracellular …

Effectiveness of non-pharmacological therapies on cognitive function in patients with dementia—A network meta-analysis of randomized controlled trials

G Luo, J Zhang, Z Song, Y Wang, X Wang… - Frontiers in Aging …, 2023 - frontiersin.org
Objective Non-pharmacological therapies (NPTs) have received increasing attention from
researchers as a category of treatment to improve cognitive impairment in patients with …