Significance: The nicotinamide adenine dinucleotide (NAD+)/reduced NAD+ (NADH) and
NADP+/reduced NADP+ (NADPH) redox couples are essential for maintaining cellular …

Significance: Diabetic cardiomyopathy (DCM) is a frequent complication occurring even in
well-controlled asymptomatic diabetic patients, and it may advance to heart failure (HF) …

Nicotinamide adenine dinucleotide (NAD+) is an essential coenzyme for various
physiological processes including energy metabolism, DNA repair, cell growth, and cell …

Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) is increased in
inflammatory bowel disease (IBD) patients, and its serum levels correlate with a worse …

Chronic hypoxia exacerbates proliferation of pulmonary arterial smooth muscle cells
(PASMC), thereby reducing the lumen of pulmonary arteries. This leads to poor blood …

Aim Glucagon‐like peptide‐1 is an incretin hormone secreted by the intestinal L‐cell with a
circadian rhythm that parallels expression of the core clock gene, Bmal1. Although feeding …

Diabetes mellitus, characterized by abnormally high blood glucose levels, gives rise to
impaired bone remodeling. In response to high glucose (HG), the attenuated osteogenic …

Aim Neurons in the arcuate nucleus of the hypothalamus are involved in regulation of food
intake and energy expenditure, and dysregulation of signalling in these neurons promotes …

Many cardiovascular diseases are associated with pathological remodeling of the
extracellular matrix (ECM) in the myocardium. ECM remodeling is a complex, multifactorial …

Heart aging is the main susceptible factor to coronary heart disease and significantly
increases the risk of heart failure, especially when the aging heart is suffering from ischemia …