Advancements in protein nanoparticle vaccine platforms to combat infectious disease

N Butkovich, E Li, A Ramirez… - Wiley …, 2021 - Wiley Online Library
Infectious diseases are a major threat to global human health, yet prophylactic treatment
options can be limited, as safe and efficacious vaccines exist only for a fraction of all …

The viral capsid as novel nanomaterials for drug delivery

AAA Aljabali, SS Hassan, RM Pabari… - Future science …, 2021 - Taylor & Francis
Lay abstract The purpose of this review is to highlight recent scientific developments and
provide an overview of virus self-assembly and viral particle dynamics. Viruses are …

Development of a SARS-CoV-2 vaccine candidate using plant-based manufacturing and a tobacco mosaic virus-like nano-particle

JM Royal, CA Simpson, AA McCormick, A Phillips… - Vaccines, 2021 - mdpi.com
Stable, effective, easy-to-manufacture vaccines are critical to stopping the COVID-19
pandemic resulting from the coronavirus SARS-CoV-2. We constructed a vaccine candidate …

Cowpea mosaic virus stimulates antitumor immunity through recognition by multiple MYD88-dependent toll-like receptors

C Mao, V Beiss, J Fields, NF Steinmetz, S Fiering - Biomaterials, 2021 - Elsevier
Cowpea mosaic virus (CPMV), a non-enveloped plant virus, and empty CPMV (eCPMV), a
virus-like particle (VLP) composed of CPMV capsid without nucleic acids, are potent in situ …

Restricted valency (NPNA)n repeats and junctional epitope-based circumsporozoite protein vaccines against Plasmodium falciparum

MD Langowski, FA Khan, S Savransky, DR Brown… - npj Vaccines, 2022 - nature.com
Abstract The Circumsporozoite Protein (CSP) of Plasmodium falciparum contains an N-
terminal region, a conserved Region I (RI), a junctional region, 25–42 copies of major …

Influenza virus-like particle (VLP) vaccines expressing the SARS-CoV-2 S glycoprotein, S1, or S2 domains

KB Chu, HJ Kang, KW Yoon, HA Lee, EK Moon… - Vaccines, 2021 - mdpi.com
The ongoing severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic
had brought disastrous consequences throughout the entire world. While several …

Surface functionalization of rod-shaped viral particles for biomedical applications

AJ Vaidya, KV Solomon - ACS applied bio materials, 2022 - ACS Publications
While synthetic nanoparticles play a very important role in modern medicine, concerns
regarding toxicity, sustainability, stability, and dispersity are drawing increasing attention to …

Comparison of protective efficacy between two DNA vaccines encoding DnaK and GroEL against fish nocardiosis

J Chen, W Wang, S Hou, W Fu, J Cai, L Xia… - Fish & Shellfish …, 2019 - Elsevier
Fish nocardiosis is a chronic granulomatous bacterial disease mainly caused by three
pathogenic bacteria, including Nocardia seriolae, N. asteroids and N. salmonicida …

Comparative evaluation of protective immunity against Francisella tularensis induced by subunit or adenovirus-vectored vaccines

M Zhao, Y Zhai, X Zai, Y Mao, E Hu, Z Wei… - Frontiers in Cellular …, 2023 - frontiersin.org
Tularemia is a highly contagious disease caused by infection with Francisella tularensis (Ft),
a pathogenic intracellular gram-negative bacterium that infects a wide range of animals and …

[HTML][HTML] Current vaccine strategies and novel approaches to combatting Francisella infection

JE Harrell, CJ Roy, JS Gunn, JB McLachlan - Vaccine, 2024 - Elsevier
Tularemia is caused by subspecies of Francisella tularensis and can manifest in a variety of
disease states, with the pneumonic presentation resulting in the greatest mortality. Despite …