Emerging novel coronavirus (2019-nCoV)—current scenario, evolutionary perspective based on genome analysis and recent developments

YS Malik, S Sircar, S Bhat, K Sharun, K Dhama… - Veterinary …, 2020 - Taylor & Francis
Coronaviruses are the well-known cause of severe respiratory, enteric and systemic
infections in a wide range of hosts including man, mammals, fish, and avian. The scientific …

[HTML][HTML] A new threat from an old enemy: Re‑emergence of coronavirus

AO Docea, A Tsatsakis… - International …, 2020 - spandidos-publications.com
The new outbreak of coronavirus from December 2019 has brought attention to an old viral
enemy and has raised concerns as to the ability of current protection measures and the …

[PDF][PDF] Structural basis for helicase-polymerase coupling in the SARS-CoV-2 replication-transcription complex

J Chen, B Malone, E Llewellyn, M Grasso… - Cell, 2020 - cell.com
SARS-CoV-2 is the causative agent of the 2019–2020 pandemic. The SARS-CoV-2 genome
is replicated and transcribed by the RNA-dependent RNA polymerase holoenzyme …

[HTML][HTML] Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR

VM Corman, O Landt, M Kaiser, R Molenkamp… - …, 2020 - eurosurveillance.org
Background The ongoing outbreak of the recently emerged novel coronavirus (2019-nCoV)
poses a challenge for public health laboratories as virus isolates are unavailable while there …

Recent discovery and development of inhibitors targeting coronaviruses

T Pillaiyar, S Meenakshisundaram, M Manickam - Drug discovery today, 2020 - Elsevier
Human coronaviruses (CoVs) are enveloped viruses with a positive-sense single-stranded
RNA genome. Currently, six human CoVs have been reported including human coronavirus …

Machine learning using intrinsic genomic signatures for rapid classification of novel pathogens: COVID-19 case study

GS Randhawa, MPM Soltysiak, H El Roz… - Plos one, 2020 - journals.plos.org
The 2019 novel coronavirus (renamed SARS-CoV-2, and generally referred to as the COVID-
19 virus) has spread to 184 countries with over 1.5 million confirmed cases. Such major viral …

Hosts and sources of endemic human coronaviruses

VM Corman, D Muth, D Niemeyer, C Drosten - Advances in virus research, 2018 - Elsevier
The four endemic human coronaviruses HCoV-229E,-NL63,-OC43, and-HKU1 contribute a
considerable share of upper and lower respiratory tract infections in adults and children …

[HTML][HTML] Vaccines for SARS-CoV-2: lessons from other coronavirus strains

E Padron-Regalado - Infectious diseases and therapy, 2020 - Springer
The emergence of the strain of coronavirus SARS-CoV-2 (severe acute respiratory
syndrome coronavirus 2) and its impact on global health have made imperative the …

Molecular epidemiology, evolution and phylogeny of SARS coronavirus

HKH Luk, X Li, J Fung, SKP Lau, PCY Woo - Infection, Genetics and …, 2019 - Elsevier
Shortly after its emergence in southern China in 2002/2003, Severe Acute Respiratory
Syndrome coronavirus (SARS-CoV) was confirmed to be the cause of SARS. Subsequently …

SARS-CoV-2 gene content and COVID-19 mutation impact by comparing 44 Sarbecovirus genomes

I Jungreis, R Sealfon, M Kellis - Nature communications, 2021 - nature.com
Despite its clinical importance, the SARS-CoV-2 gene set remains unresolved, hindering
dissection of COVID-19 biology. We use comparative genomics to provide a high …