The p53 protein, encoded by the TP53 gene, serves as a critical tumor suppressor, playing a
vital role in maintaining genomic stability and regulating cellular responses to stress …

Currently, various antimitotic inhibitors applied in tumor therapy. However, these inhibitors
exhibit targeted toxicity to some extent. As a motor protein, kinesin family member 18A …

Lung cancer is one of the most common malignant tumors. Despite decades of research, the
treatment of lung cancer remains challenging. Non-small cell lung cancer (NSCLC) is the …

Here, we report recurrent focal deletions of the chr14q32. 31-32 locus, including TRAF3, a
negative regulator of NF-κB signaling, in de novo diffuse large B cell lymphoma …

KIF18B is a key member of the kinesin-8 family, involved in regulating various physiological
processes such as microtubule length, spindle assembly, and chromosome alignment. This …

Breast cancer (BC) is one of the most common types of cancer among women worldwide.
Lycorine (Lycoris radiata), a small molecule derived from the traditional Chinese herb …

Gastric cancer (GC) is a main cause of cancer death in the world, and improving the
chemotherapy sensitivity can enhance the chemotherapy efficacy of GC. The study objective …

In this issue, Rovsing et al. employ unbiased genome‐wide CRISPR screening and
functional cellular assays to investigate the cellular response to vincristine, an important …

Mitotic inhibitors, such as Vinca alkaloids and taxanes, are one of the most effective
chemotherapeutic agents used in the clinic. Despite their advantages, there are drawbacks …

The work presented in this PhD thesis was conducted between 2020-2024 during my time
as a PhD student and research assistant at the Department of Hematology, Aalborg …