Advantages of the combinatorial molecular targeted therapy of head and neck cancer—A step before anakoinosis-based personalized treatment
R Kleszcz - Cancers, 2023 - mdpi.com
Simple Summary Head and Neck Squamous Cell Carcinoma (HNSCC) is a major threat to
public health around the world. Its occurrence is linked to genetic events and environmental …
public health around the world. Its occurrence is linked to genetic events and environmental …
[HTML][HTML] Novel DNA targeted therapies for head and neck cancers: clinical potential and biomarkers
M Glorieux, R Dok, S Nuyts - Oncotarget, 2017 - ncbi.nlm.nih.gov
Head and neck squamous cell carcinoma is the sixth most common cancer worldwide and
despite advances in treatment over the last years, there is still a relapse rate of 50%. New …
despite advances in treatment over the last years, there is still a relapse rate of 50%. New …
Genome-wide open reading frame profiling identifies fibroblast growth factor signaling as a driver of PD-L1 expression in head and neck squamous cell carcinoma
JE Mann, JD Smith, A Kulkarni, SK Foltin, EB Scheftz… - Oral Oncology, 2023 - Elsevier
Head and neck squamous cell carcinomas (HNSCC) are associated with significant
treatment-related morbidity and poor disease-free and disease-specific survival, especially …
treatment-related morbidity and poor disease-free and disease-specific survival, especially …
PIK3CA gene mutations in HNSCC: Systematic review and correlations with HPV status and patient survival
Simple Summary Mutations of the PIK3CA gene are thought to contribute to the
development of head and neck squamous cell carcinomas (HNSCC), especially those …
development of head and neck squamous cell carcinomas (HNSCC), especially those …
The PI3K/Akt/mTORC signaling axis in head and neck squamous cell carcinoma: Possibilities for therapeutic interventions either as single agents or in combination …
N Akbari Dilmaghani, A Safaroghli‐Azar… - IUBMB …, 2021 - Wiley Online Library
The latest advances in the sequencing methods in head and neck squamous cell carcinoma
(HNSCC) tissues have revolutionized our understanding of the disease by taking off the veil …
(HNSCC) tissues have revolutionized our understanding of the disease by taking off the veil …
[HTML][HTML] The inhibitors of KDM4 and KDM6 histone lysine demethylases enhance the anti-growth effects of erlotinib and HS-173 in head and neck cancer cells
R Kleszcz, M Skalski, V Krajka-Kuźniak… - European Journal of …, 2021 - Elsevier
Novel therapeutics are required to improve treatment outcomes in head and neck squamous
cell carcinoma (HNSCC) patients. Histone lysine demethylases (KDM) have emerged …
cell carcinoma (HNSCC) patients. Histone lysine demethylases (KDM) have emerged …
ABCB1 and ABCG2 overexpression mediates resistance to the phosphatidylinositol 3-kinase inhibitor HS-173 in cancer cell lines
CP Wu, CY Hung, YJ Hsieh, M Murakami, YH Huang… - Cells, 2023 - mdpi.com
Constitutive activation of the phosphoinositide-3-kinase (PI3K)/Akt signaling pathway is
crucial for tumor growth and progression. As such, this pathway has been an enticing target …
crucial for tumor growth and progression. As such, this pathway has been an enticing target …
The influence of PI3K inhibition on the radiotherapy response of head and neck cancer cells
M Glorieux, R Dok, S Nuyts - Scientific Reports, 2020 - nature.com
Radiotherapy has a central role in the treatment of head and neck squamous cell carcinoma
(HNSCC). Activation of the PI3K/AKT/mTOR pathway can decrease the efficiency of …
(HNSCC). Activation of the PI3K/AKT/mTOR pathway can decrease the efficiency of …
The genomic landscape of UM-SCC oral cavity squamous cell carcinoma cell lines
Objectives We sought to describe the genetic complexity of 14 UM-SCC oral cavity cancer
cell lines that have remained uncharacterized despite being used as model systems for …
cell lines that have remained uncharacterized despite being used as model systems for …
ERK-dependent IL-6 autocrine signaling mediates adaptive resistance to pan-PI3K inhibitor BKM120 in head and neck squamous cell carcinoma
MR Yun, HM Choi, HN Kang, Y Lee, HS Joo, DH Kim… - Oncogene, 2018 - nature.com
Hyperactivation of phosphatidylinositol 3-kinase (PI3K) pathway occurs frequently in head
and neck squamous cell carcinoma (HNSCC). However, clinical outcomes of targeting the …
and neck squamous cell carcinoma (HNSCC). However, clinical outcomes of targeting the …