Effective and safe proton pump inhibitor therapy in acid-related diseases–a position paper addressing benefits and potential harms of acid suppression

C Scarpignato, L Gatta, A Zullo, C Blandizzi… - BMC medicine, 2016 - Springer
Background The introduction of proton pump inhibitors (PPIs) into clinical practice has
revolutionized the management of acid-related diseases. Studies in primary care and …

[HTML][HTML] The indications, applications, and risks of proton pump inhibitors: A review after 25 years

J Mössner - Deutsches Ärzteblatt International, 2016 - ncbi.nlm.nih.gov
Background Proton pump inhibitors (PPI) are the most effective drugs for inhibiting gastric
acid secretion. They have been in clinical use for more than 25 years, In 2014, 3.475 billion …

Austrian consensus guidelines on the management and treatment of portal hypertension (Billroth III)

T Reiberger, A Püspök, M Schoder… - Wiener klinische …, 2017 - Springer
The Billroth III guidelines were developed during a consensus meeting of the Austrian
Society of Gastroenterology and Hepatology (ÖGGH) and the Austrian Society of …

S2k-leitlinie gastrointestinale blutung

M Goetz, M Anders, E Biecker… - Zeitschrift für …, 2017 - thieme-connect.com
Diese interdisziplinäre Leitlinie unter Leitung der DGVS und Beteiligung benachbarter
Fachgesellschaften fasst die wichtigsten Aspekte zur Versorgung von Patienten mit …

Guidelines for the management of adult acute and acute-on-chronic liver failure in the ICU: neurology, peri-transplant medicine, infectious disease, and …

R Nanchal, R Subramanian, W Alhazzani… - Critical care …, 2023 - journals.lww.com
OBJECTIVES: To develop evidence-based recommendations for clinicians caring for adults
with acute liver failure (ALF) or acute on chronic liver failure (ACLF) in the ICU. DESIGN: The …

Safe use of proton pump inhibitors in patients with cirrhosis

RA Weersink, M Bouma, DM Burger… - British Journal of …, 2018 - Wiley Online Library
Aims Proton pump inhibitors (PPIs) belong to the most frequently used drugs, also in
patients with cirrhosis. PPIs are extensively metabolized by the liver, but practice guidance …

Stop of proton-pump inhibitor treatment in patients with liver cirrhosis (STOPPIT): study protocol for a prospective, multicentre, controlled, randomized, double-blind …

MH Wehmeyer, T Horvatits, A Buchholz, L Krause… - Trials, 2022 - Springer
Background Proton-pump inhibitors (PPI) are liberally prescribed in patients with liver
cirrhosis. Observational studies link PPI therapy in cirrhotic patients with an increased risk …

[HTML][HTML] Aktualisierte S2k-leitlinie der deutschen gesellschaft für gastroenterologie, verdauungs-und stoffwechselkrankheiten (DGVS)„komplikationen der …

AL Gerbes, J Labenz, B Appenrodt… - Zeitschrift für …, 2019 - thieme-connect.com
Die Leitlinie Komplikationen der Leberzirrhose der Deutschen Gesellschaft für
Gastroenterologie, Verdauungs-und Stoffwechselkrankheiten (DGVS) ersetzt die Leitlinie …

Proton pump inhibitors are associated with accelerated development of cirrhosis, hepatic decompensation and hepatocellular carcinoma in noncirrhotic patients with …

DK Li, P Yan, AB Abou‐Samra… - Alimentary …, 2018 - Wiley Online Library
Background Proton pump inhibitors are among the most commonly prescribed medications
in the United States. Their safety in cirrhosis has recently been questioned, but their overall …

Deleterious effect of proton pump inhibitors on the disease course of cirrhosis

T Janka, T Tornai, B Borbély, D Tornai… - European journal of …, 2020 - journals.lww.com
Objectives Proton pump inhibitors (PPIs) are widely prescribed to patients with liver
cirrhosis. We hypothesized that long-standing PPI use is associated with spontaneous …