The discovery that gene expression can be controlled by the Watson–Crick base-pairing of
small RNAs with messenger RNAs containing complementary sequence—a process known …

Through a mechanism known as RNA interference (RNAi), small interfering RNA (siRNA)
molecules can target complementary mRNA strands for degradation, thus specifically …

Thousands of long non-coding RNAs (lncRNAs) have been identified in mammalian cells.
Some have important functions and their dysregulation can contribute to a variety of disease …

RNA interference (RNAi) was discovered less than a decade ago and already there are
human clinical trials in progress or planned. A major advantage of RNAi versus other …

Prostate cancer cells expressing prostate-specific membrane antigen (PSMA) have been
targeted with RNA aptamer–small interfering (si) RNA chimeras, but therapeutic efficacy in …

Although microRNAs (miRNAs) are key regulators of gene expression, little is known of their
overall persistence in the cell following processing. Characterization of such persistence is …

RNA interference (RNAi) is a unique treatment approach used to decrease a disease's
excessive gene expression, including cancer. SiRNAs may find and destroy homologous …

Well over a hundred reports have been published describing use of synthetic small-
interfering RNAs (siRNAs) in animals. The majority of these reports employed unmodified …

RNA interference (RNAi) has become the method of choice to suppress gene expression in
vitro. It is also emerging as a powerful tool for in vivo research with over 90 studies …

Our recent advancements in RNA nanotechnology introduced novel nanoscaffolds
(nanorings); however, the potential of their use for biomedical applications was never fully …