Botulinum toxin as a pain killer: players and actions in antinociception
DW Kim, SK Lee, J Ahnn - Toxins, 2015 - mdpi.com
Botulinum neurotoxins (BoNTs) have been widely used to treat a variety of clinical ailments
associated with pain. The inhibitory action of BoNTs on synaptic vesicle fusion blocks the …
associated with pain. The inhibitory action of BoNTs on synaptic vesicle fusion blocks the …
Architecture of the botulinum neurotoxin complex: a molecular machine for protection and delivery
Highlights•Botulinum neurotoxins are highly potent oral toxins.•The large progenitor
complex of BoNT is a bimodular 14-subunit complex.•NTNHA protects BoNT in the acidic …
complex of BoNT is a bimodular 14-subunit complex.•NTNHA protects BoNT in the acidic …
The long journey of botulinum neurotoxins into the synapse
A Rummel - Toxicon, 2015 - Elsevier
Botulinum neurotoxins (BoNT) cause the disease botulism, a flaccid paralysis of the muscle.
They are also very effective, widely used medicines applied locally in sub-nanogram …
They are also very effective, widely used medicines applied locally in sub-nanogram …
The structure of the tetanus toxin reveals pH‐mediated domain dynamics
G Masuyer, J Conrad, P Stenmark - EMBO reports, 2017 - embopress.org
The tetanus neurotoxin (Te NT) is a highly potent toxin produced by Clostridium tetani that
inhibits neurotransmission of inhibitory interneurons, causing spastic paralysis in the tetanus …
inhibits neurotransmission of inhibitory interneurons, causing spastic paralysis in the tetanus …
A viral-fusion-peptide-like molecular switch drives membrane insertion of botulinum neurotoxin A1
Botulinum neurotoxin (BoNT) delivers its protease domain across the vesicle membrane to
enter the neuronal cytosol upon vesicle acidification. This process is mediated by its …
enter the neuronal cytosol upon vesicle acidification. This process is mediated by its …
Generation and characterization of six recombinant botulinum neurotoxins as reference material to serve in an international proficiency test
J Weisemann, N Krez, U Fiebig, S Worbs, M Skiba… - Toxins, 2015 - mdpi.com
The detection and identification of botulinum neurotoxins (BoNT) is complex due to the
existence of seven serotypes, derived mosaic toxins and more than 40 subtypes. Expert …
existence of seven serotypes, derived mosaic toxins and more than 40 subtypes. Expert …
Diverse binding modes, same goal: The receptor recognition mechanism of botulinum neurotoxin
Botulinum neurotoxins (BoNTs) are among the most deadly toxins known. They act rapidly in
a highly specific manner to block neurotransmitter release by cleaving the soluble N …
a highly specific manner to block neurotransmitter release by cleaving the soluble N …
Dynamic intramolecular regulation of the histone chaperone nucleoplasmin controls histone binding and release
C Warren, T Matsui, JM Karp, T Onikubo… - Nature …, 2017 - nature.com
Nucleoplasmin (Npm) is a highly conserved histone chaperone responsible for the maternal
storage and zygotic release of histones H2A/H2B. Npm contains a pentameric N-terminal …
storage and zygotic release of histones H2A/H2B. Npm contains a pentameric N-terminal …
Protein arginine methyltransferase 8: tetrameric structure and protein substrate specificity
Type I protein arginine methyltransferases (PRMTs) catalyze asymmetric dimethylation of
various proteins, and their dysregulations often correlate with tumorigenesis or …
various proteins, and their dysregulations often correlate with tumorigenesis or …
The cryo‐EM structure of the BoNT/Wo‐NTNH complex reveals two immunoglobulin‐like domains
The botulinum neurotoxin‐like toxin from Weissella oryzae (BoNT/Wo) is one of the BoNT‐
like toxins recently identified outside of the Clostridium genus. We show that, like the …
like toxins recently identified outside of the Clostridium genus. We show that, like the …