The human cathelicidin hCAP18/LL-37 has become a paradigm for the pleiotropic roles of
peptides in host defence. It has a remarkably wide functional repertoire that includes direct …

Notwithstanding ceaseless endeavors toward developing effective antibiofilm
chemotherapeutics, biofilm-associated infections continue to be one of the most perplexing …

Antimicrobial peptides (AMPs) are potent antibiotics of the innate immune system that have
been extensively investigated as a potential solution to the global problem of infectious …

Background. A major issue is finding a valid biomarker able to diagnose periodontal disease
with the presence and absence of risk factors. Indeed, the association between smoking and …

Background Rosacea is a chronic inflammatory disease characterized by centrofacial
erythema. Excess cathelicidin is suggested to be important to the pathophysiology of the …

Lung cysteine cathepsins B, K, L, and S contribute to physiological and pathological
processes including degradation of antimicrobial peptides/proteins (AMPs) such as …

Leptospirosis remains one of the most widespread zoonotic diseases caused by spirochetes
of the genus Leptospira, which accounts for high morbidity and mortality globally …

Cathelicidins are a ubiquitous family of host defence antimicrobial peptides in vertebrate
animals. Unlike other antimicrobial peptide families, it is defined by a large and relatively …

Leptospirosis causes significant morbidity and mortality worldwide; however, the role of the
host immune response in disease progression and high case fatality (> 10–50%) is poorly …

Background: Ischemic heart disease (IHD) is the most prevalent type of cardiovascular
disease. The main cause of IHD is atherosclerosis, which is a multifactorial inflammatory …