Titin: a tunable spring in active muscle

K Nishikawa - Physiology, 2020 - journals.physiology.org
Muscle has conventionally been viewed as a motor that converts chemical to kinetic energy
in series with a passive spring, but new insights emerge when muscle is viewed as a …

[图书][B] Science and practice of strength training

VM Zatsiorsky, WJ Kraemer, AC Fry - 2020 - books.google.com
Science and Practice of Strength Training is a favorite book among strength and
conditioning professionals. Now in a third edition, it offers upgraded artwork, updates based …

A Conceptual Exploration of Hamstring Muscle–Tendon Functioning during the Late-Swing Phase of Sprinting: The Importance of Evidence-Based Hamstring Training …

JT Kalkhoven, M Lukauskis-Carvajal, DL Sides… - Sports Medicine, 2023 - Springer
An eccentrically lengthening, energy-absorbing, brake-driven model of hamstring function
during the late-swing phase of sprinting has been widely touted within the existing literature …

[HTML][HTML] Basic science and clinical use of eccentric contractions: history and uncertainties

KC Nishikawa, SL Lindstedt, PC LaStayo - Journal of sport and health …, 2018 - Elsevier
The peculiar attributes of muscles that are stretched when active have been noted for nearly
a century. Understandably, the focus of muscle physiology has been primarily on shortening …

Calcium-dependent titin–thin filament interactions in muscle: observations and theory

K Nishikawa, S Dutta, M DuVall, B Nelson… - Journal of Muscle …, 2020 - Springer
Gaps in our understanding of muscle mechanics demonstrate that the current model is
incomplete. Increasingly, it appears that a role for titin in active muscle contraction might …

Effects of a titin mutation on force enhancement and force depression in mouse soleus muscles

U Tahir, JA Monroy, NA Rice… - Journal of …, 2020 - journals.biologists.com
The active isometric force produced by muscles varies with muscle length in accordance
with the force–length relationship. Compared with isometric contractions at the same final …

N2A titin: signaling hub and mechanical switch in skeletal muscle

K Nishikawa, SL Lindstedt, A Hessel… - International Journal of …, 2020 - mdpi.com
Since its belated discovery, our understanding of the giant protein titin has grown
exponentially from its humble beginning as a sarcomeric scaffold to recent recognition of its …

Understanding muscle function during perturbed in vivo locomotion using a muscle avatar approach

N Rice, CM Bemis, MA Daley… - Journal of …, 2023 - journals.biologists.com
The work loop technique has provided key insights into in vivo muscle work and power
during steady locomotion. However, for many animals and muscles, ex vivo experiments are …

Force re-development after shortening reveals a role for titin in stretch–shortening performance enhancement in skinned muscle fibres

A Tomalka, S Weidner, D Hahn… - Journal of …, 2024 - journals.biologists.com
Stretch–shortening cycles (SSCs) involve muscle lengthening (eccentric contractions)
instantly followed by shortening (concentric contractions). This combination enhances force …

Non-cross bridge viscoelastic elements contribute to muscle force and work during stretch-shortening cycles: evidence from whole muscles and permeabilized fibers

AL Hessel, JA Monroy, KC Nishikawa - Frontiers in Physiology, 2021 - frontiersin.org
The sliding filament–swinging cross bridge theory of skeletal muscle contraction provides a
reasonable description of muscle properties during isometric contractions at or near …