Cranial placodes are specialized regions of the ectoderm, which give rise to various sensory
ganglia and contribute to the pituitary gland and sensory organs of the vertebrate head …

During the last decades, many studies have investigated the transcriptional and epigenetic
regulation of lineage decision in the hematopoietic system. These efforts led to a model in …

The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that bind
as dimers to specific DNA target sites and that have been well characterized in nonplant …

Bone marrow is the tissue filling the space between bone surfaces. Hematopoietic stem cells
(HSCs) are maintained by special microenvironments known as niches within bone marrow …

Background Molecular and genetic analyses conducted in model organisms such as
Drosophila and vertebrates, have provided a wealth of information about how networks of …

The Ebf (O/E) family of helix-loop-helix transcription factors plays a significant role in B
lymphocyte and neuronal development. The three primary members of this family, Ebf1, 2 …

GnRH neurons follow a carefully orchestrated journey from their birth in the olfactory
placode area. Initially, they migrate along with the vomeronasal nerve into the brain at the …

In contrast to most well-studied model organisms, planarians have a remarkable ability to
completely regenerate a functional nervous system from a pluripotent stem cell population …

In a complex nervous system, neuronal functional diversity is reflected in the wide variety of
dendritic arbor shapes. Different neuronal classes are defined by class-specific transcription …

Fibroblast growth factor (FGF) signalling regulates essential developmental processes in
vertebrates and invertebrates, but its role during early metazoan evolution remains obscure …