BACKGROUND The integrated stress response (ISR) is an evolutionarily conserved
intracellular signaling network that helps the cell, tissue, and organism to adapt to a variable …

Treatment of tuberculosis (TB) remains challenging, with lengthy treatment durations and
complex drug regimens that are toxic and difficult to administer. Similar to the vast majority of …

Introduction: Activating transcription factor 4 (ATF4) is a member of the activating
transcription factor family. ATF4 expression is increased in response to a diverse array of …

Host-directed therapies are a relatively new and promising approach to treatment of
tuberculosis. Modulation of specific host immune pathways, including those that impact …

Abstract The Pathogen Box is a 400‐strong collection of drug‐like compounds, selected for
their potential against several of the world's most important neglected tropical diseases …

Introduction: The eIF2α kinase heme-regulated inhibitor (HRI) is one of four well-described
kinases that phosphorylate eIF2α in response to various cell stressors, resulting in reduced …

The ability to block biological processes with selective small molecules provides advantages
distinct from most other experimental approaches. These include rapid time to onset, swift …

Metabolic disorders are becoming more common in young population due to increased
consumption of carbohydrate rich diet, lack of physical activity and stress. Fructose is used …

Mycobacterium tuberculosis (Mtb) has coevolved with a human host to evade and exploit the
immune system in multiple ways. Mtb is an enormously successful human pathogen that can …

Highlights•Drug-resistant infections threaten many of the core advances in healthcare.•New
collaborative approaches to early-stage hit and lead generation are needed.•Collaborative …