Lipid droplets (LDs) contribute to key pathways important for the physiology and
pathophysiology of cells. In a homeostatic view, LDs regulate the storage of neutral lipids …

Tuberculosis, an infectious disease caused by Mycobacterium tuberculosis (Mtb), remains a
major cause of human death worldwide. Innate immunity provides host defense against Mtb …

Several large-scale genome-wide association studies genetically linked IRGM to Crohn's
disease and other inflammatory disorders in which the IRGM appears to have a protective …

From epidemiological data, based on concordance data in family studies, via linkage
analysis to genome-wide association studies, we and others have accumulated robust …

Crohn's disease (CD) is a chronic, immune-mediated, inflammatory disorder of the intestine
that has been linked to numerous susceptibility genes, including the immunity-related …

Toll-like receptors (TLRs) serve as the major innate immune sensors for detection of specific
molecular patterns on various pathogens. TLRs activate signaling events mainly by utilizing …

Ebola hemorrhagic fever (EHF) is a severe viral infection for which no effective treatment or
vaccine is currently available. While the nonhuman primate (NHP) model is used for final …

The zebrafish genome contains ten genes that encode class II cytokine-like peptides, of
which the two that are related most closely to mammalian interferon gamma (IFN-γ) were …

Inflammation associated with gram‐negative bacterial infections is often instigated by the
bacterial cell wall component lipopolysaccharide (LPS). LPS‐induced inflammation and …

Chlamydiae are obligate intracellular bacterial pathogens that exhibit a broad range of host
tropism. Differences in host tropism between Chlamydia species have been linked to host …