The naphthoquinone shikonin is the main active principle of Zicao, a traditional Chinese
herbal medicine made from the dried root of Lithospermum erythrorhizon. Studies carried …

Parkinson's disease (PD) is a degenerative disease that affects approximately 6.1 million
people and is primarily caused by the loss of dopaminergic neurons. Naphthoquinones …

Acetaminophen (APAP) overdose causes acute liver injury and leads to fatal liver damage.
However, the therapies are quite limited. Shikonin is a natural product with antioxidant and …

Excessive accumulation of β-amyloid (Aβ) is thought to be a major causative factor in the
pathogenesis of Alzheimer's disease (AD). Pretreating Aβ-induced neurotoxicity is a …

Shikonin is one of the major bioactive components of Lithospermum erythrorhizon. It has a
good killing effect in a variety of tumor cells. Its antitumor effect involves multiple targets and …

Abstract The SENP1 (Sentrin-Specific Protease1) is essential for desumoylation. SENP1
plays an essential role in many diseases such as cardiovascular disease, diabetes and …

The nervous system has a highly complex organization, including many cell types with
multiple functions, with an intricate anatomy and unique structural and functional …

Lithospermum officinale was used traditionally as a remedy in diseases of the urogenital
tract and as a spasmolytic, antidiarrhoeal, diuretic and lithotriptic, anti-gout, antitoxic …

Parkinson's disease (PD) is the second most common neurodegenerative disorder. Shikonin
plays protective roles in age‐associated diseases. Therefore, we investigate the biological …

Cervical spondylotic myelopathy (CSM) is a clinically symptomatic entity arising from the
spinal cord compression by degenerative diseases. Although endoplasmic reticulum (ER) …