Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR-
associated (Cas) systems have revolutionized biological and biomedical sciences in many …

The versatility of RNA in sensing and interacting with small molecules, proteins and other
nucleic acids while encoding genetic instructions for protein translation makes it a powerful …

Detection of analytes by means of field-effect transistors bearing ligand-specific receptors is
fundamentally limited by the shielding created by the electrical double layer (the “Debye …

We present a generalizable approach for designing biosensors that can continuously detect
small-molecule biomarkers in real time and without sample preparation. This is achieved by …

Luminescence quenching is a process exploited in transversal applications in science and
technology and it has been studied for a long time. The luminescence quenching …

We report artificial nanopores in the form of quartz nanopipettes with ca. 10 nm orifices
functionalized with molecular recognition elements termed aptamers that reversibly …

Portable devices capable of rapid disease detection and health monitoring are crucial to
decentralizing diagnostics from clinical laboratories to the patient point-of-need. Although …

Electrochemical aptamer-based (E-AB) sensors, which have rapid responsiveness, have
been widely used in the area of analytical chemistry. 1 In view of low analyte abundance …

The DNA aptamer for adenosine (also for AMP and ATP) is a highly conserved sequence
that has recurred in a few selections. It it a widely used model aptamer for biosensor …

The desire to improve and decentralize diagnostic platforms to facilitate highly precise and
personalized medicine has motivated the development of a large number of electrochemical …