Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine that acts on multiple cell
lineages, including dendritic cells, T cells, B cells, neutrophils, mast cells, eosinophils and …

Allergic diseases such as allergic rhinitis (AR), allergic asthma (AAS), atopic dermatitis (AD),
food allergy (FA), and eczema are systemic diseases caused by an impaired immune …

Environmental pollution is one of the most serious challenges to health in the modern world.
Pollutants alter immune responses and can provoke immunotoxicity. In this Review, we …

The skin serves as the primary interface between our body and the external environment
and acts as a barrier against entry of physical agents, chemicals, and microbes …

Atopic dermatitis (AD) is a public health concern and is increasing in prevalence in urban
areas. Recent advances in sequencing technology have demonstrated that the development …

Atopic dermatitis (AD) is a common, chronic-relapsing inflammatory skin disease with
significant disease burden. Genetic and environmental trigger factors contribute to AD …

Proteases are signaling molecules that specifically control cellular functions by cleaving
protease-activated receptors (PARs). The four known PARs are members of the large family …

The initiation of type 2 immune responses by the epithelial cell–derived cytokines IL-25, IL-
33 and TSLP has been an area of extensive research in the past decade. Such studies have …

Atopic dermatitis often precedes the development of other atopic diseases. The atopic march
describes this temporal relationship in the natural history of atopic diseases. Although the …

For centuries, itch was categorized as a submodality of pain. Recent research over the last
decade has led to the realization that itch is in fact a separate and distinct, albeit closely …