Genomes 5 has been completely revised and updated. It is a thoroughly modern textbook
about genomes and how they are investigated. As with previous Genomes editions …

Genetic alterations, including DNA mutations and chromosomal abnormalities, are primary
drivers of tumor formation and cancer progression. These alterations can endow cells with a …

Transcription-coupled nucleotide-excision repair (TC-NER) is a subpathway of NER that
efficiently removes the highly toxic RNA polymerase II blocking lesions in DNA. Defective TC …

The principle of synthetic lethality, which refers to the loss of viability resulting from the
disruption of two genes, which, individually, do not cause lethality, has become an attractive …

DNA double‐strand break (DSB) is a serious type of DNA damage and is known to trigger
multiple responses within cells. In these responses, novel relationships among DSB, DSB …

Damage repair mechanisms at transcriptionally active sites during the G0/G1 phase are
largely unknown. To elucidate these mechanisms, we introduced genome site-specific …

Transcriptional arrest caused by DNA damage is detrimental for cells and organisms as it
impinges on gene expression and thereby on cell growth and survival. To alleviate …

UV-sensitive syndrome (UVSS) is an autosomal recessive disorder characterized by
photosensitivity and deficiency in transcription-coupled repair (TCR), a subpathway of …

Cockayne syndrome (CS) is a segmental premature aging syndrome caused primarily by
defects in the CSA or CSB genes. In addition to premature aging, CS patients typically …

Nucleotide excision repair (NER) is a versatile pathway that removes helix-distorting DNA
lesions from the genomes of organisms across the evolutionary scale, from bacteria to …