Gene therapy represents a promising cancer treatment featuring high efficacy and limited
side effects, but it is stymied by a lack of safe and efficient gene-delivery vectors. Cationic …

Abstract Poly (β‐amino ester)(abbreviated as PBAE or PAE) refers to a polymer synthesized
from an acrylate and an amine by Michael addition and has properties inherent to tertiary …

The study of cellular processes occurring inside intact organisms requires methods to
visualize cellular functions such as gene expression in deep tissues. Ultrasound is a widely …

Introduction Gene delivery technologies are being developed for an increasing number of
biomedical applications, with delivery vehicles including viruses and non-viral materials …

Current glioblastoma therapies are insufficient to prevent tumor recurrence and eventual
death. Here, we describe a method to treat malignant glioma by nonviral DNA delivery using …

siRNA nanomedicines can potentially treat many human diseases, but safe and effective
delivery remains a challenge. DNA delivery polymers such as poly (β-amino ester) s …

Lipid nanoparticles (LNPs) carrying therapeutic mRNAs hold great promise in treating lung-
associated diseases like viral infections, tumors, and genetic disorders. However, because …

Non-viral gene therapy for hereditary skin diseases is an attractive prospect. However,
research efforts dedicated to this area are rare. Taking advantage of the branched structural …

Novel treatments for glioblastoma (GBM) are urgently needed, particularly those which can
simultaneously target GBM cells' ability to grow and migrate. Herein, we describe a …

Size-dependent phagocytosis is a well-characterized phenomenon in monocytes and
macrophages. However, this size effect for preferential gene delivery to these important cell …