With the rising incidences of antimicrobial resistance (AMR) and the diminishing options of
novel antimicrobial agents, it is paramount to decipher the molecular mechanisms of action …

Recent advances in molecular dynamics (MD) simulations have led to rapid improvement in
our understanding of the molecular details of the outer membranes (OMs) of Gram-negative …

Antimicrobial peptides (AMPs) can be directed to specific membranes based on differences
in lipid composition. In this study, we performed atomistic and coarse-grained simulations of …

AntiMicrobial Resistance (AMR) is a worldwide health emergency. ESKAPE pathogens
include the most relevant AMR bacterial families. In particular, Gram-negative bacteria stand …

Diderm bacteria employ β‐barrel outer membrane proteins (OMPs) as their first line of
communication with their environment. These OMPs are assembled efficiently in the …

Lipopolysaccharide (LPS) is a complex glycolipid molecule that is the main lipidic
component of the outer leaflet of the outer membrane of Gram-negative bacteria. It has very …

The current issue (volume 13 issue 6, 2021) is a Special Issue jointly dedicated to scientific
content presented at the 20th triennial IUPAB Congress that was held in conjunction with …

In Gram-negative bacteria, N-terminal lipidation is a signal for protein trafficking from the
inner membrane (IM) to the outer membrane (OM). The IM complex LolCDE extracts …

Because of the limited number of antibiotics available and the similarities in their activity and
mode of action, considerable nonclinical and clinical research is being spent in the …

Antimicrobial resistance (AMR) is a major global health threat, with estimates forecasting 10
million annual AMR-induced deaths by 2050. Antimicrobial peptides (AMP) are molecules …