Enzymatic carbon–sulfur bond formation in natural product biosynthesis

KL Dunbar, DH Scharf, A Litomska… - Chemical …, 2017 - ACS Publications
Sulfur plays a critical role for the development and maintenance of life on earth, which is
reflected by the wealth of primary metabolites, macromolecules, and cofactors bearing this …

[HTML][HTML] Mechanistic concepts of iron-sulfur protein biogenesis in Biology

JJ Braymer, SA Freibert, M Rakwalska-Bange… - Biochimica et Biophysica …, 2021 - Elsevier
Abstract Iron-sulfur (Fe/S) proteins are present in virtually all living organisms and are
involved in numerous cellular processes such as respiration, photosynthesis, metabolic …

A widespread bacterial protein compartment sequesters and stores elemental sulfur

R Benisch, MP Andreas, TW Giessen - Science Advances, 2024 - science.org
Subcellular compartments often serve to store nutrients or sequester labile or toxic
compounds. As bacteria mostly do not possess membrane-bound organelles, they often …

Structure and functional dynamics of the mitochondrial Fe/S cluster synthesis complex

MT Boniecki, SA Freibert, U Mühlenhoff, R Lill… - Nature …, 2017 - nature.com
Abstract Iron–sulfur (Fe/S) clusters are essential protein cofactors crucial for many cellular
functions including DNA maintenance, protein translation, and energy conversion. De novo …

Bacterial approaches for assembling iron-sulfur proteins

K Esquilin-Lebron, S Dubrac, F Barras, JM Boyd - Mbio, 2021 - Am Soc Microbiol
Building iron-sulfur (Fe-S) clusters and assembling Fe-S proteins are essential actions for
life on Earth. The three processes that sustain life, photosynthesis, nitrogen fixation, and …

Encapsulins

TW Giessen - Annual review of biochemistry, 2022 - annualreviews.org
Subcellular compartmentalization is a defining feature of all cells. In prokaryotes,
compartmentalization is generally achieved via protein-based strategies. The two main …

The many facets of sulfur incorporation in natural product biosynthesis

AD Steele, AF Kiefer, B Shen - Current Opinion in Chemical Biology, 2023 - Elsevier
Sulfur-containing natural products (S-containing NPs) exhibit diverse chemical structures
and biosynthetic machineries. Unraveling the intricate chemistry of S-incorporation requires …

Discovery and characterization of a novel family of prokaryotic nanocompartments involved in sulfur metabolism

RJ Nichols, B LaFrance, NR Phillips, DR Radford… - Elife, 2021 - elifesciences.org
Prokaryotic nanocompartments, also known as encapsulins, are a recently discovered
proteinaceous organelle-like compartment in prokaryotes that compartmentalize cargo …

Bacterial pathogens: threat or treat (a review on bioactive natural products from bacterial pathogens)

F Maglangit, Y Yu, H Deng - Natural Product Reports, 2021 - pubs.rsc.org
Covering: up to the second quarter of 2020 Threat or treat? While pathogenic bacteria pose
significant threats, they also represent a huge reservoir of potential pharmaceuticals to treat …

Biochemical reconstitution and spectroscopic analysis of iron–sulfur proteins

SA Freibert, BD Weiler, E Bill, AJ Pierik… - Methods in …, 2018 - Elsevier
Abstract Iron–sulfur (Fe/S) proteins are involved in numerous key biological functions such
as respiration, metabolic processes, protein translation, DNA synthesis, and DNA repair. The …