The biological applications of DNA nanomaterials: current challenges and future directions

W Ma, Y Zhan, Y Zhang, C Mao, X Xie… - Signal transduction and …, 2021 - nature.com
DNA, a genetic material, has been employed in different scientific directions for various
biological applications as driven by DNA nanotechnology in the past decades, including …

Block copolymer micelles in nanomedicine applications

H Cabral, K Miyata, K Osada, K Kataoka - Chemical reviews, 2018 - ACS Publications
Polymeric micelles are demonstrating high potential as nanomedicines capable of
controlling the distribution and function of loaded bioactive agents in the body, effectively …

Chemo-physical Strategies to Advance the in Vivo Functionality of Targeted Nanomedicine: The Next Generation

J Li, K Kataoka - Journal of the American Chemical Society, 2020 - ACS Publications
The past few decades have witnessed an evolution of nanomedicine from biologically inert
entities to more smart systems, aimed at advancing in vivo functionality. However, we should …

Temperature-responsive multilayer films of micelle-based composites for controlled release of a third-generation EGFR inhibitor

L Xu, H Wang, Z Chu, L Cai, H Shi, C Zhu… - ACS Applied Polymer …, 2020 - ACS Publications
Lung cancer is a complicated long-term disease, which is extremely difficult to cure. A
traditional single drug delivery system cannot achieve desired long-term controlled release …

Controlling the biodistribution and clearance of nanomedicines

H Cabral, J Li, K Miyata, K Kataoka - Nature Reviews Bioengineering, 2024 - nature.com
Nanomedicines improve drug bioavailability, the dose–response relationship, targeting
ability, efficacy and safety compared to conventional freely administered drugs …

Nonviral cancer gene therapy: delivery cascade and vector nanoproperty integration

Z Zhou, X Liu, D Zhu, Y Wang, Z Zhang, X Zhou… - Advanced drug delivery …, 2017 - Elsevier
Gene therapy represents a promising cancer treatment featuring high efficacy and limited
side effects, but it is stymied by a lack of safe and efficient gene-delivery vectors. Cationic …

Synthetic polypeptides: from polymer design to supramolecular assembly and biomedical application

Z Song, Z Han, S Lv, C Chen, L Chen, L Yin… - Chemical Society …, 2017 - pubs.rsc.org
Synthetic polypeptides from the ring-opening polymerization of N-carboxyanhydrides
(NCAs) are one of the most important biomaterials. The unique features of these synthetic …

Temperature-responsive smart nanocarriers for delivery of therapeutic agents: applications and recent advances

M Karimi, P Sahandi Zangabad… - … applied materials & …, 2016 - ACS Publications
Smart drug delivery systems (DDSs) have attracted the attention of many scientists, as
carriers that can be stimulated by changes in environmental parameters such as …

Nanomedicine-based approaches for mRNA delivery

S Uchida, F Perche, C Pichon… - Molecular …, 2020 - ACS Publications
Messenger RNA (mRNA) has immense potential for developing a wide range of therapies,
including immunotherapy and protein replacement. As mRNA presents no risk of integration …

Stimuli-responsive polymeric nanoplatforms for cancer therapy

D Chang, Y Ma, X Xu, J Xie, S Ju - Frontiers in bioengineering and …, 2021 - frontiersin.org
Polymeric nanoparticles have been widely used as carriers of drugs and bioimaging agents
due to their excellent biocompatibility, biodegradability, and structural versatility. The …