Pathogenic potential of adipose tissue and metabolic consequences of adipocyte hypertrophy and increased visceral adiposity

HE Bays, JM González-Campoy, GA Bray… - Expert review of …, 2008 - Taylor & Francis
When caloric intake exceeds caloric expenditure, the positive caloric balance and storage of
energy in adipose tissue often causes adipocyte hypertrophy and visceral adipose tissue …

The biochemistry of diabetes.

R Taylor, L Agius - Biochemical Journal, 1988 - ncbi.nlm.nih.gov
The hallmark of diabetes mellitus is an inability to control blood glucose. There are two
major clinical syndromes: one characterized by insulin dependence and early age of onset …

[HTML][HTML] Obesity is associated with macrophage accumulation in adipose tissue

SP Weisberg, D McCann, M Desai… - The Journal of …, 2003 - Am Soc Clin Investig
Obesity alters adipose tissue metabolic and endocrine function and leads to an increased
release of fatty acids, hormones, and proinflammatory molecules that contribute to obesity …

[HTML][HTML] Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the …

S Marshall, V Bacote, RR Traxinger - Journal of Biological Chemistry, 1991 - Elsevier
Based on our previous finding that desensitization of the insulin-responsive glucose
transport system (GTS) requires three components, glucose, insulin, and glutamine, we …

Glucose uptake and perfusion in subcutaneous and visceral adipose tissue during insulin stimulation in nonobese and obese humans

KA Virtanen, P Lönnroth, R Parkkola… - The Journal of …, 2002 - academic.oup.com
To elucidate the role of adipose tissue glucose uptake in whole-body metabolism, sc and
visceral adipose tissue glucose uptake and perfusion were measured in 10 nonobese and …

[HTML][HTML] Transcriptional repression of the GLUT4 and C/EBP genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha.

JM Stephens, PH Pekala - Journal of Biological Chemistry, 1991 - Elsevier
Fully differentiated 3T3-L1 adipocytes were chronically exposed to 5 nM tumor necrosis
factor-alpha (TNF). This resulted in the development of an insulin resistance based on the …

An in vitro human muscle preparation suitable for metabolic studies. Decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic …

GL Dohm, EB Tapscott, WJ Pories… - The Journal of …, 1988 - Am Soc Clin Investig
We have developed an in vitro muscle preparation suitable for metabolic studies with human
muscle tissue and have investigated the effects of obesity and non-insulin-dependent …

Insulin-stimulated translocation of glucose transporters in the isolated rat adipose cells: characterization of subcellular fractions

IA Simpson, DR Yver, PJ Hissin, LJ Wardzala… - … et Biophysica Acta (BBA …, 1983 - Elsevier
Insulin stimulates glucose transport in rat adipose cells through the translocation of glucose
transporters from an intracellular pool to the plasma membrane. A detailed characterization …

In vivo kinetics of insulin action on peripheral glucose disposal and hepatic glucose output in normal and obese subjects

R Prager, P Wallace, JM Olefsky - The Journal of clinical …, 1986 - Am Soc Clin Investig
To determine whether abnormal kinetics of insulin's biologic actions contribute to the overall
insulin resistance in obesity, we compared the rate of activation and deactivation of insulin's …

Insulin resistance in obese Zucker rat (fa/fa) skeletal muscle is associated with a failure of glucose transporter translocation.

PA King, ED Horton, MF Hirshman… - The Journal of clinical …, 1992 - Am Soc Clin Investig
The genetically obese Zucker rat (fa/fa) is characterized by a severe resistance to the action
of insulin to stimulate skeletal muscle glucose transport. The goal of the present study was to …