In recent years, the chromatin field has witnessed a renewed interest in histone variants as
pertaining to their structural role, but mainly because of the functional specificity they impart …

Facilitates chromatin transcription (FACT) plays essential roles in chromatin remodeling
during DNA transcription, replication, and repair. Our structural and biochemical studies of …

Histones are the protein components of the nucleosome, which forms the basic architecture
of eukaryotic chromatin. Histones H2A, H2B, H3, and H4 are composed of two common …

Genetic and epigenetic information in eukaryotic cells is carried on chromosomes, basically
consisting of large compact supercoiled chromatin fibers. Micromanipulations have recently …

Magnetic tweezers were used to study the mechanical response under torsion of single
nucleosome arrays reconstituted on tandem repeats of 5S positioning sequences. Regular …

CENP-A is a histone variant that replaces conventional H3 in nucleosomes of functional
centromeres. We report here, from reconstitutions of CENP-A-and H3-containing …

Facilitates chromatin transcription (FACT) is a histone chaperone, which accomplishes both
nucleosome assembly and disassembly. Our combined cryo-electron microscopy (EM) and …

In Eukaryotes, DNA is wound around the histone octamer forming the basic chromatin unit,
the nucleosome. Atomic structures have been obtained from crystallography and single …

We have reported earlier the occurrence of a specific histone H2B variant in human testis
and sperm. Here we have structurally characterized this protein, its association with the rest …

We here present a modeling study of the chromatin fiber functional organization. Multi-scale
modeling is required to unravel the complex interplay between the fiber and the DNA levels …