The treatment of central nervous system (CNS) malignancies, including brain cancers, is
limited by a number of obstructions, including the blood-brain barrier (BBB), the …

The condensation of 5-aminopyrazole with various bielectrophilic moieties results in the
formation of pyrazoloazines, an interesting array of fused heterocyclic systems. The …

Tetramethylpyrazine (TMP) has been effectively used for treating spinal cord injury (SCI) due
to its anti-inflammatory, antioxidant, and neuroprotective activity. However, its clinical …

Abstract Pyrazolo [3, 4-d] pyrimidine ring system constitute an important class of heterocyclic
compounds which can serve as a promising scaffold exhibiting many pharmacological …

In this work, the authors prepared and characterized two different graphene oxides: one
chemically synthesized (GO sample) and the other one electrochemically synthesized (GO …

A series of novel hybrid pyrazolo [3, 4-d] pyramidine derivatives was designed and
chemically synthesized in useful yields. The synthesized compounds were structurally …

Background Nanoparticles (NPs) have been emerging as potential players in modern
medicine with clinical applications ranging from therapeutic purposes to antimicrobial …

The inherent properties of albumin facilitate its effective use as a raw material to prepare a
nanosized drug delivery vehicles. Because of the enhanced surface area, biocompatibility …

In this study, docetaxel loaded nanoparticles were synthesized and labeled with 131 I for
diagnosis and treatment of prostate cancer. Docetaxel (DTX) was loaded onto human serum …

Si306, a pyrazolo [3, 4-d] pyrimidine derivative recently identified as promising anticancer
agent, has shown favorable in vitro and in vivo activity profile against neuroblastoma (NB) …