Quantitative phase imaging: recent advances and expanding potential in biomedicine

TL Nguyen, S Pradeep, RL Judson-Torres, J Reed… - ACS …, 2022 - ACS Publications
Quantitative phase imaging (QPI) is a label-free, wide-field microscopy approach with
significant opportunities for biomedical applications. QPI uses the natural phase shift of light …

100 years of Brillouin scattering: Historical and future perspectives

M Merklein, IV Kabakova, A Zarifi… - Applied Physics …, 2022 - pubs.aip.org
The Year 2022 marks 100 years since Leon Brillouin predicted and theoretically described
the interaction of optical waves with acoustic waves in a medium. Accordingly, this resonant …

Brillouin light scattering: applications in biomedical sciences

F Palombo, D Fioretto - Chemical reviews, 2019 - ACS Publications
Brillouin spectroscopy and imaging are emerging techniques in analytical science,
biophotonics, and biomedicine. They are based on Brillouin light scattering from acoustic …

Durotaxis: the hard path from in vitro to in vivo

A Shellard, R Mayor - Developmental cell, 2021 - cell.com
Durotaxis, the process by which cells follow gradients of extracellular mechanical stiffness,
has been proposed as a mechanism driving directed migration. Despite the lack of evidence …

High-sensitivity and high-specificity biomechanical imaging by stimulated Brillouin scattering microscopy

I Remer, R Shaashoua, N Shemesh, A Ben-Zvi… - Nature …, 2020 - nature.com
Label-free, non-contact imaging with mechanical contrast and optical sectioning is a
substantial challenge in microscopy. Spontaneous Brillouin scattering microscopy meets this …

Mapping mechanical properties of biological materials via an add-on Brillouin module to confocal microscopes

J Zhang, G Scarcelli - Nature protocols, 2021 - nature.com
Several techniques have been developed over the past few decades to assess the
mechanical properties of biological samples, which has fueled a rapid growth in the fields of …

Understanding the mechanobiology of early mammalian development through bioengineered models

S Vianello, MP Lutolf - Developmental cell, 2019 - cell.com
Research in developmental biology has been recently enriched by a multitude of in vitro
models recapitulating key milestones of mammalian embryogenesis. These models obviate …

Time-lapse mechanical imaging of neural tube closure in live embryo using Brillouin microscopy

C Handler, G Scarcelli, J Zhang - Scientific Reports, 2023 - nature.com
Neural tube closure (NTC) is a complex process of embryonic development involving
molecular, cellular, and biomechanical mechanisms. While the genetic factors and …

Harnessing quantum light for microscopic biomechanical imaging of cells and tissues

T Li, V Cheburkanov, VV Yakovlev, GS Agarwal… - Proceedings of the …, 2024 - pnas.org
The biomechanical properties of cells and tissues play an important role in our fundamental
understanding of the structures and functions of biological systems at both the cellular and …

Tissue biomechanics during cranial neural tube closure measured by Brillouin microscopy and optical coherence tomography

J Zhang, R Raghunathan, J Rippy, C Wu… - Birth defects …, 2019 - Wiley Online Library
Background Embryonic development involves the interplay of driving forces that shape the
tissue and the mechanical resistance that the tissue offers in response. While increasing …