More and more in-depth studies have revealed that the occurrence and development of
tumors depend on gene mutation and tumor heterogeneity. The most important …

Protein-protein interactions (PPIs) are well-established as a class of promising drug targets
for their implications in a wide range of biological processes. However, drug development …

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor and an
attractive therapeutic target for cancer and other human diseases. Despite 20 years of …

Protein neddylation is a post-translational modification, and its best recognized substrates
are cullin family proteins, which are the core component of Cullin-RING ligases (CRLs) …

NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an
ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate …

Post-translational modifications of proteins ensure optimized cellular processes, including
proteostasis, regulated signaling, cell survival, and stress adaptation to maintain a balanced …

Abstract NEDD8-conjugating enzymes, E2s, include the well-studied ubiquitin-conjugating
enzyme E2 M (UBE2M) and the poorly characterized ubiquitin-conjugating enzyme E2 F …

Ubiquitin-conjugating enzyme E2 M (UBE2M) and ubiquitin-conjugating enzyme E2 F
(UBE2F) are the two NEDD8-conjugating enzymes of the neddylation pathway that take part …

Protein neddylation is a post-translational modification which transfers the ubiquitin-like
protein NEDD8 to a lysine residue of the target substrate through a three-step enzymatic …

Neddylation is the writing of monomers or polymers of neural precursor cells expressed
developmentally down-regulated 8 (NEDD8) to substrate. For neddylation to occur, three …