The composition of intestinal microbiota is influenced by a number of factors, including
medications, which may have a substantial impact on host physiology. Nonsteroidal anti …

The gut microbiome plays critical roles in human health and disease. Recent studies
suggest it may also be associated with chronic pain and postoperative pain outcomes. In …

Substance use disorders (SUDs) represent a significant public health crisis. Worldwide,
5.4% of the global disease burden is attributed to SUDs and alcohol use, and many more …

Gut microbiota is a complex ecosystem seen as an extension of human genome. It
represents a major metabolic interface of interaction with food components and xenobiotics …

Murine models suggest that opioids alter the gut microbiota, which may impact opioid
tolerance and psychopathology. We examined how gut microbiota characteristics related to …

Opioid drugs are widely used to treat chronic pain, but their misuse can lead to tolerance,
dependence, and addiction and have created a significant public health problem. In …

Background Schizophrenia is a serious long-term psychotic disorder marked by positive and
negative symptoms, severe behavioral problems and cognitive function deficits. The cause …

We compared endogenous ω-3 PUFA production to supplementation for improving obesity-
related metabolic dysfunction. Fat-1 transgenic mice, who endogenously convert exogenous …

Abstract μ-Opioid receptors (MORs) are densely expressed in different brain regions known
to mediate reward. One such region is the striatum where MORs are densely expressed, yet …

The intestinal microecology is a research hotspot, and neologisms related to the gut such as
gut-brain axis, gut-lung axis, gut-bone axis, gut-skin axis, gut-renal axis, and gut-liver axis …