The beneficial effects of physical activity on brain ageing are well recognised, with
exerkines, factors that are secreted into the circulation in response to exercise, emerging as …

Exercise has been shown to have beneficial effects on brain functions in humans and
animals. Exercise can improve memory and learning in age-related neurodegenerative …

It is becoming increasingly clear that interactions between the peripheral immune system
and the central nervous system are important in maintaining healthy brain function. Platelets …

Physical activity is a strong positive physiological modulator of adult neurogenesis in the
hippocampal dentate gyrus. Although the underlying regulatory mechanisms are still …

Cellular redox states regulate the balance between stem cell maintenance and activation.
Increased levels of intracellular reactive oxygen species (ROS) are linked to proliferation …

Evidence for experience-dependent structural brain change in adult humans is
accumulating. However, its time course is not well understood, as intervention studies …

Here, we show that the lysophosphatidic acid receptor 1 (LPA 1) is expressed by a defined
population of type 1 stem cells and type 2a precursor cells in the adult mouse dentate gyrus …

Physical exercise stimulates adult hippocampal neurogenesis and is considered a relevant
strategy for preventing age-related cognitive decline in humans. The underlying …

Astrocytes are highly abundant in the mammalian brain, and their functions are of vital
importance for all aspects of development, adaption, and aging of the central nervous …

Scientific theories on the functioning and dysfunction of the human brain require an
understanding of its development—before and after birth and through maturation to …