TET-mediated active DNA demethylation: mechanism, function and beyond
In mammals, DNA methylation in the form of 5-methylcytosine (5mC) can be actively
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …
The threat of programmed DNA damage to neuronal genome integrity and plasticity
KW Caldecott, ME Ward, A Nussenzweig - Nature Genetics, 2022 - nature.com
The neuronal genome is particularly sensitive to loss or attenuation of DNA repair, and many
neurological diseases ensue when DNA repair is impaired. It is well-established that the …
neurological diseases ensue when DNA repair is impaired. It is well-established that the …
Reprogramming to recover youthful epigenetic information and restore vision
Ageing is a degenerative process that leads to tissue dysfunction and death. A proposed
cause of ageing is the accumulation of epigenetic noise that disrupts gene expression …
cause of ageing is the accumulation of epigenetic noise that disrupts gene expression …
Gamma frequency entrainment attenuates amyloid load and modifies microglia
Abstract Changes in gamma oscillations (20–50 Hz) have been observed in several
neurological disorders. However, the relationship between gamma oscillations and cellular …
neurological disorders. However, the relationship between gamma oscillations and cellular …
Different neuronal activity patterns induce different gene expression programs
KM Tyssowski, NR DeStefino, JH Cho, CJ Dunn… - Neuron, 2018 - cell.com
A vast number of different neuronal activity patterns could each induce a different set of
activity-regulated genes. Mapping this coupling between activity pattern and gene induction …
activity-regulated genes. Mapping this coupling between activity pattern and gene induction …
[HTML][HTML] Formation of memory assemblies through the DNA-sensing TLR9 pathway
As hippocampal neurons respond to diverse types of information, a subset assembles into
microcircuits representing a memory. Those neurons typically undergo energy-intensive …
microcircuits representing a memory. Those neurons typically undergo energy-intensive …
TET (Ten-eleven translocation) family proteins: structure, biological functions and applications
X Zhang, Y Zhang, C Wang, X Wang - Signal Transduction and …, 2023 - nature.com
Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …
EGR1 recruits TET1 to shape the brain methylome during development and upon neuronal activity
Life experience can leave lasting marks, such as epigenetic changes, in the brain. How life
experience is translated into storable epigenetic information remains largely unknown. With …
experience is translated into storable epigenetic information remains largely unknown. With …
[HTML][HTML] Region-specific transcriptional control of astrocyte function oversees local circuit activities
Astrocytes play essential roles in brain function by supporting synaptic connectivity and
associated circuits. How these roles are regulated by transcription factors is unknown …
associated circuits. How these roles are regulated by transcription factors is unknown …