The spike protein (S-protein) of SARS-CoV-2, the protein that enables the virus to infect
human cells, is the basis for many vaccines and a hotspot of concerning virus evolution …

The recent revolution in cryo electron microscopy (cryo-EM) allows the determination of
structures of macromolecular complexes at atomic resolution. Cryo-EM also provides …

Understanding Alzheimer's disease is a central challenge of the 21st century, as the disease
affects tens of millions of people and kills a million people each year, with current drugs …

Molecules are essential building blocks of life and their different conformations (ie, shapes)
crucially determine the functional role that they play in living organisms. Cryogenic Electron …

Abstract γ-Secretase is an aspartyl intramembrane protease that cleaves the amyloid
precursor protein (APP) involved in Alzheimer's disease pathology and other …

γ-Secretase cleaves the C99 fragment of the amyloid precursor protein, leading to formation
of aggregated β-amyloid peptide central to Alzheimer's disease, and Notch, essential for cell …

Human γ-secretase cleaves the transmembrane domains (TMDs) of amyloid precursor
protein (APP) into pathologically relevant amyloid-β peptides (Aβs). The detailed …

The 4-subunit intramembrane protease complex γ-secretase cleaves many substrates
including fragments of the β-amyloid precursor protein (APP), leading to formation of Aβ …

Protein fold stability likely plays a role in SARS-CoV-2 S-protein evolution, together with
ACE2 binding and antibody evasion. While few thermodynamic stability data are available …

The binding affinity of the SARS-CoV-2 spike (S)-protein to the human membrane protein
ACE2 is critical for virus function. Computational structure-based screening of new S-protein …