Growth-associated protein-43 (GAP-43) and brain acid-soluble protein 1 (BASP1) regulate
actin dynamics and presynaptic vesicle cycling at axon terminals, thereby facilitating axonal …

In a number of animal species, the growth-associated protein (GAP), GAP-43 (aka: F1,
neuromodulin, B-50, G50, pp46), has been implicated in the regulation of presynaptic …

In Alzheimer's disease, amyloid-beta (Aβ) triggers the trans-synaptic spread of tau
pathology, and aberrant synaptic activity has been shown to promote tau spreading. Aβ …

GAP-43 is an intracellular growth-associated protein that appears to assist neuronal
pathfinding and branching during development and regeneration, and may contribute to …

Major brain functions depend on neuronal processes that favor the plasticity of neuronal
circuits while at the same time maintaining their stability. The mechanisms that regulate …

The presynaptic α-synuclein is a prime suspect for contributing to Lewy pathology and
clinical aspects of diseases, including Parkinson's disease, dementia with Lewy bodies, and …

Rab GTPases are central elements of the vesicular transport machinery. An emerging view
is that downstream effectors of these GTPases are multiprotein complexes that include …

Ramón y Cajal proposed 100 years ago that memory formation requires the growth of nerve
cell processes. One-half century later, Hebb suggested that growth of presynaptic axons and …

Protein kinase CK2 is a ubiquitous and pleiotropic seryl/threonyl protein kinase which is
highly conserved in evolution indicating a vital cellular role for this kinase. The holoenzyme …

Plasticity in the central nervous system in response to injury is a complex process involving
axonal remodeling regulated by specific molecular pathways. Here, we dissected the role of …