The epidemic nature of diabetes mellitus in different regions is reviewed. The Middle East
and North Africa region has the highest prevalence of diabetes in adults (10.9%) whereas …

Genetic risk variants that have been identified in genome-wide association studies of
complex diseases are primarily non-coding. Translating these risk variants into mechanistic …

To maximize the potential of genome‐wide association studies, many researchers are
performing secondary analyses to identify sets of genes jointly associated with the trait of …

We report the largest and most diverse genetic study of type 1 diabetes (T1D) to date
(61,427 participants), yielding 78 genome-wide-significant (P< 5× 10− 8) regions, including …

Integrating single nucleotide polymorphism (SNP) p-values from genome-wide association
studies (GWAS) across genes and pathways is a strategy to improve statistical power and …

Background Around 0.3% of newborns will develop autoimmunity to pancreatic beta cells in
childhood and subsequently develop type 1 diabetes before adulthood. Primary prevention …

Determining whether potential causal variants for related diseases are shared can identify
overlapping etiologies of multifactorial disorders. Colocalization methods disentangle …

Progress in defining the genetics of autoimmune disease has been dramatically enhanced
by large scale genetic studies. Genome-wide approaches, examining hundreds or for some …

OBJECTIVE Type 1 diabetes (T1D) is a highly heritable disease with much lower incidence
but more adult-onset cases in the Chinese population. Although genome-wide association …

In type 1 diabetes (T1D) autoreactive CD8 T cells infiltrate pancreatic islets and destroy
insulin-producing β cells. Progression to T1D onset is a chronic process, which suggests …