[图书][B] Bioanalytical tools in water quality assessment

P Neale, F Leusch, B Escher - 2021 - library.oapen.org
The first edition of Bioanalytical Tools in Water Quality Assessment was released in 2012.
The field has exploded since and the second edition updates and reviews the application of …

A perfusion incubator liver chip for 3D cell culture with application on chronic hepatotoxicity testing

F Yu, R Deng, W Hao Tong, L Huan, N Chan Way… - Scientific reports, 2017 - nature.com
Liver chips have been developed to recapitulate in vivo physiological conditions to enhance
hepatocyte functions for assessing acute responses to drugs. To develop liver chips that can …

Three-dimensionally engineered biomimetic tissue models for in vitro drug evaluation: delivery, efficacy and toxicity

Y Peck, DA Wang - Expert opinion on drug delivery, 2013 - Taylor & Francis
Introduction: Three-dimensionally (3D) engineered biomimetic tissue models are sought
after due to their high fidelity in mimicking various native tissues of the human body, this …

Long‐term liver‐specific functions of hepatocytes in electrospun chitosan nanofiber scaffolds coated with fibronectin

D Rajendran, A Hussain, D Yip… - … Research Part A, 2017 - Wiley Online Library
In this study, a new 3D liver model was developed using biomimetic nanofiber scaffolds and
co‐culture system consisting of hepatocytes and fibroblasts for the maintenance of long …

[HTML][HTML] Pre-clinical assessment of the potential intrinsic hepatotoxicity of candidate drugs

JJ van Tonder, V Steenkamp… - New insights into toxicity …, 2013 - intechopen.com
Innovation is fundamental to discovering new drugs for the variety of human conditions that
exist. It is also one of the key requirements for any pharmaceutical organization that wishes …

Liver Organoids: Construction, Characterization, and Applications

A Guo, H Yu, X Yan, Y Du - EMERGING TECHNOLOGIES IN …, 2023 - World Scientific
Liver organoids are three-dimensional multicellular in vitro tissue constructs mimicking
developmental or adult liver microenvironment; thus, it can be applied to study various …

Zastosowanie modeli in vitro w przedklinicznych badaniach bezpieczeństwa nowych kandydatów na leki

K Klaś, P Guzy, K Piska, K Wójcik-Pszczoła… - Farmacja …, 2018 - ruj.uj.edu.pl
abstrakt w j. polskim: Modele in vitro to podstawowe narzędzie umożliwiające ustalenie
profilu aktywności i sprawdzenie bezpieczeństwa kandydata na lek na etapie badań …

Effects of surface functionalization and physical constraints of poly (dimethylsiloxane) on cellular behaviors

S Kuddannaya - 2017 - dr.ntu.edu.sg
Mammalian cell behaviors are highly regulated by the complex cell microenvironments. In
vitro models with precise manipulation of cell-substrate interactions can provide realistic …

[HTML][HTML] Development of organotypic liver cell cultures in three-dimensional biomaterial hydrogels

M Malinen - 2014 - helda.helsinki.fi
New organotypic liver cell cultures are needed to predict the metabolism, excretion, and
safety of chemical compounds. Liver cell models are particularly important since the liver …

Development of 3-d liver model for drug screening applications

D Rajendran - 2012 - digitalcommons.njit.edu
The need for a an in vitro drug screening system that mimics the structural organization of
natural liver for multi-functionality and maintenance of hepatocytes has become vital in the …