Plasmodium sporozoites are the product of a complex developmental process in the
mosquito vector and are destined to infect the mammalian liver. Attention has been drawn to …

Malaria is caused by protozoan parasites of the genus Plasmodium and involves infection of
multiple hosts and cell types during the course of an infection. To complete its complex life …

Plasmodium sporozoites are transmitted from infected mosquitoes to mammals, and must
navigate the host skin and vasculature to infect the liver. This journey requires distinct …

The molecular mechanisms underlying transcriptional regulation in apicomplexan parasites
remain poorly understood. Recently, the Apicomplexan AP2 (ApiAP2) family of DNA binding …

The malaria parasite life cycle alternates between two hosts: a vertebrate and the female
Anopheles mosquito vector. Cell division, proliferation, and invasion are essential for …

Malaria infections of mammals are initiated by the transmission of Plasmodium salivary
gland sporozoites during an Anopheles mosquito vector bite. Sporozoites make their way …

Plasmodium gene functions in mosquito and liver stages remain poorly characterized due to
limitations in the throughput of phenotyping at these stages. To fill this gap, we followed …

Immunization of humans with whole sporozoites confers complete, sterilizing immunity
against malaria infection. However, achieving consistent safety while maintaining …

In malaria, the red blood cell-infectious form of the Plasmodium parasite causes illness and
the possible death of infected hosts. The initial infection in the liver caused by the mosquito …

Malaria vaccine development has rapidly advanced in the past decade. The very first phase
3 clinical trial of the RTS, S vaccine was completed with over 15,000 African infants and …