Matrix metalloproteinases shape the tumor microenvironment in cancer progression
S Niland, AX Riscanevo, JA Eble - International journal of molecular …, 2021 - mdpi.com
Cancer progression with uncontrolled tumor growth, local invasion, and metastasis depends
largely on the proteolytic activity of numerous matrix metalloproteinases (MMPs), which …
largely on the proteolytic activity of numerous matrix metalloproteinases (MMPs), which …
[HTML][HTML] Membrane-type matrix metalloproteinases: Their functions and regulations
Y Itoh - Matrix Biology, 2015 - Elsevier
Membrane-type matrix metalloproteinases (MT-MMPs) form a subgroup of the matrix
metalloproteinase (MMP) family, and there are 6 MT-MMPs in humans. MT-MMPs are further …
metalloproteinase (MMP) family, and there are 6 MT-MMPs in humans. MT-MMPs are further …
[HTML][HTML] MT1-MMP-dependent control of skeletal stem cell commitment via a β1-integrin/YAP/TAZ signaling axis
In vitro, topographical and biophysical cues arising from the extracellular matrix (ECM) direct
skeletal stem cell (SSC) commitment and differentiation. However, the mechanisms by which …
skeletal stem cell (SSC) commitment and differentiation. However, the mechanisms by which …
CLASPs link focal-adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover
SJ Stehbens, M Paszek, H Pemble, A Ettinger… - Nature cell …, 2014 - nature.com
Turnover of integrin-based focal adhesions (FAs) with the extracellular matrix (ECM) is
essential for coordinated cell movement. In collectively migrating human keratinocytes, FAs …
essential for coordinated cell movement. In collectively migrating human keratinocytes, FAs …
Osteoclast-mediated bone resorption is controlled by a compensatory network of secreted and membrane-tethered metalloproteinases
Osteoclasts actively remodel both the mineral and proteinaceous components of bone
during normal growth and development as well as pathologic states ranging from …
during normal growth and development as well as pathologic states ranging from …
Control of SARS-CoV-2 infection by MT1-MMP-mediated shedding of ACE2
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global
pandemic. Angiotensin-converting enzyme 2 (ACE2) is an entry receptor for SARS-CoV-2 …
pandemic. Angiotensin-converting enzyme 2 (ACE2) is an entry receptor for SARS-CoV-2 …
Signaling inputs to invadopodia and podosomes
D Hoshino, KM Branch, AM Weaver - Journal of cell science, 2013 - journals.biologists.com
Remodeling of extracellular matrix (ECM) is a fundamental cell property that allows cells to
alter their microenvironment and move through tissues. Invadopodia and podosomes are …
alter their microenvironment and move through tissues. Invadopodia and podosomes are …
[HTML][HTML] Membrane-type matrix metalloproteases as diverse effectors of cancer progression
SP Turunen, O Tatti-Bugaeva, K Lehti - Biochimica et Biophysica Acta (BBA …, 2017 - Elsevier
Membrane-type matrix metalloproteases (MT-MMP) are pivotal regulators of cell invasion,
growth and survival. Tethered to the cell membranes by a transmembrane domain or GPI …
growth and survival. Tethered to the cell membranes by a transmembrane domain or GPI …
MT1-MMP-dependent cell migration: proteolytic and non-proteolytic mechanisms
V Gifford, Y Itoh - Biochemical Society Transactions, 2019 - portlandpress.com
Membrane-type 1 matrix metalloproteinase (MT1-MMP) is a type I transmembrane
proteinase that belongs to the matrix metalloproteinase (MMP) family. It is a potent modifier …
proteinase that belongs to the matrix metalloproteinase (MMP) family. It is a potent modifier …
Body weight regulation via MT1-MMP-mediated cleavage of GFRAL
GDNF-family receptor a-like (GFRAL) has been identified as the cognate receptor of
growth/differentiation factor 15 (GDF15/MIC-1), considered a key signaling axis in energy …
growth/differentiation factor 15 (GDF15/MIC-1), considered a key signaling axis in energy …