[HTML][HTML] SARS-CoV-2 variant biology: immune escape, transmission and fitness

AM Carabelli, TP Peacock, LG Thorne… - Nature Reviews …, 2023 - nature.com
In late 2020, after circulating for almost a year in the human population, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibited a major step change in its …

[HTML][HTML] Clinical implications of host genetic variation and susceptibility to severe or critical COVID-19

CI van der Made, MG Netea… - Genome …, 2022 - genomemedicine.biomedcentral …
Since the start of the coronavirus disease 2019 (COVID-19) pandemic, important insights
have been gained into virus biology and the host factors that modulate the human immune …

COVID-19: Clinical features

K McIntosh, MS Hirsch, A Bloom - UpToDate®.(Accessed on Dec 1 …, 2021 - uptodate.com
INTRODUCTION—Coronaviruses are important human and animal pathogens. At the end of
2019, a novel coronavirus was identified as the cause of a cluster of pneumonia cases in …

Risk factors of severe COVID-19: a review of host, viral and environmental factors

L Zsichla, V Müller - Viruses, 2023 - mdpi.com
The clinical course and outcome of COVID-19 are highly variable, ranging from
asymptomatic infections to severe disease and death. Understanding the risk factors of …

[HTML][HTML] Proteome-wide Mendelian randomization implicates nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity

S Yoshiji, G Butler-Laporte, T Lu, JDS Willett, CY Su… - Nature …, 2023 - nature.com
Obesity is a major risk factor for Coronavirus disease (COVID-19) severity; however, the
mechanisms underlying this relationship are not fully understood. As obesity influences the …

[HTML][HTML] COVID-19-Related Age Profiles for SARS-CoV-2 Variants in England and Wales and States of the USA (2020 to 2022): Impact on All-Cause Mortality

RP Jones, A Ponomarenko - Infectious Disease Reports, 2023 - mdpi.com
Since 2020, COVID-19 has caused serious mortality around the world. Given the ambiguity
in establishing COVID-19 as the direct cause of death, we first investigate the effects of age …

[HTML][HTML] miRNAs as a Potential Biomarker in the COVID-19 Infection and Complications Course, Severity, and Outcome

M Jankovic, D Nikolic, I Novakovic, B Petrovic… - Diagnostics, 2023 - mdpi.com
During the last three years, since the emergence of the COVID-19 pandemic, a significant
number of scientific publications have focused on resolving susceptibility to the infection, as …

[HTML][HTML] Better safe than sorry—Whole-genome sequencing indicates that missense variants are significant in susceptibility to COVID-19

D Słomian, J Szyda, P Dobosz, J Stojak… - PLoS …, 2023 - journals.plos.org
Undoubtedly, genetic factors play an important role in susceptibility and resistance to COVID-
19. In this study, we conducted the GWAS analysis. Out of 15,489,173 SNPs, we identified …

[HTML][HTML] Biological effects of COVID-19 on lung cancer: Can we drive our decisions

B Aramini, V Masciale, AV Samarelli, R Tonelli… - Frontiers in …, 2022 - frontiersin.org
COVID-19 infection caused by SARS-CoV-2 is considered catastrophic because it affects
multiple organs, particularly those of the respiratory tract. Although the consequences of this …

[HTML][HTML] Lack of effectiveness of Bebtelovimab monoclonal antibody among high-risk patients with SARS-Cov-2 Omicron during BA. 2, BA. 2.12. 1 and BA. 5 …

S Sridhara, AB Gungor, HK Erol, M Al-Obaidi… - Plos one, 2023 - journals.plos.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariants are
expected to be resistant to Bebtelovimab (BEB) monoclonal antibody (MAb) and the real …