Regulation and function of mTOR signalling in T cell fate decisions
H Chi - Nature reviews immunology, 2012 - nature.com
The evolutionarily conserved kinase mTOR (mammalian target of rapamycin) couples cell
growth and metabolism to environmental inputs in eukaryotes. T cells depend on mTOR …
growth and metabolism to environmental inputs in eukaryotes. T cells depend on mTOR …
mTOR signaling at the crossroads of environmental signals and T‐cell fate decisions
The evolutionarily conserved serine/threonine kinase mTOR (mechanistic target of
rapamycin) forms the distinct protein complexes mTORC1 and mTORC2 and integrates …
rapamycin) forms the distinct protein complexes mTORC1 and mTORC2 and integrates …
Pancreatic islet-specific engineered Tregs exhibit robust antigen-specific and bystander immune suppression in type 1 diabetes models
Adoptive transfer of regulatory T cells (Tregs) is therapeutic in type 1 diabetes (T1D) mouse
models. Tregs that are specific for pancreatic islets are more potent than polyclonal Tregs in …
models. Tregs that are specific for pancreatic islets are more potent than polyclonal Tregs in …
Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants
V De Rosa, M Galgani, A Porcellini, A Colamatteo… - Nature …, 2015 - nature.com
Human regulatory T cells (Treg cells) that develop from conventional T cells (Tconv cells)
following suboptimal stimulation via the T cell antigen receptor (TCR)(induced Treg cells …
following suboptimal stimulation via the T cell antigen receptor (TCR)(induced Treg cells …
Regulation of T helper cell fate by TCR signal strength
ND Bhattacharyya, CG Feng - Frontiers in immunology, 2020 - frontiersin.org
T cells are critical in orchestrating protective immune responses to cancer and an array of
pathogens. The interaction between a peptide MHC (pMHC) complex on antigen presenting …
pathogens. The interaction between a peptide MHC (pMHC) complex on antigen presenting …
Early signaling events that underlie fate decisions of naive CD4+ T cells toward distinct T‐helper cell subsets
H Yamane, WE Paul - Immunological reviews, 2013 - Wiley Online Library
Summary CD 4+ T‐helper (Th) cells are a major cell population that play an important role in
governing acquired immune responses to a variety of foreign antigens as well as inducing …
governing acquired immune responses to a variety of foreign antigens as well as inducing …
Regulatory T cells in cancer
D Mougiakakos, A Choudhury, A Lladser… - Advances in cancer …, 2010 - Elsevier
At the present time, regulatory T cells (Tregs) are an integral part of immunology but the
route from discovery of “suppressive” lymphocytes in the 1980s to the current established …
route from discovery of “suppressive” lymphocytes in the 1980s to the current established …
FOXO transcription factors throughout T cell biology
SM Hedrick, RH Michelini, AL Doedens… - Nature Reviews …, 2012 - nature.com
The outcome of an infection with any given pathogen varies according to the dosage and
route of infection, but, in addition, the physiological state of the host can determine the …
route of infection, but, in addition, the physiological state of the host can determine the …
Estrogen receptor α contributes to T cell–mediated autoimmune inflammation by promoting T cell activation and proliferation
It has long been appreciated that most autoimmune disorders are characterized by
increased prevalence in females, suggesting a potential role for sex hormones in the …
increased prevalence in females, suggesting a potential role for sex hormones in the …
TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo
RA Gottschalk, E Corse, JP Allison - Journal of Experimental Medicine, 2010 - rupress.org
T cell receptor (TCR) ligation is required for the extrathymic differentiation of forkhead box
p3+ (Foxp3+) regulatory T cells. Several lines of evidence indicate that weak TCR …
p3+ (Foxp3+) regulatory T cells. Several lines of evidence indicate that weak TCR …