Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

ML Block, L Zecca, JS Hong - Nature Reviews Neuroscience, 2007 - nature.com
Mounting evidence indicates that microglial activation contributes to neuronal damage in
neurodegenerative diseases. Recent studies show that in response to certain environmental …

[HTML][HTML] An overview of ferroptosis in non-alcoholic fatty liver disease

S Wang, Z Liu, J Geng, L Li, X Feng - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a public health problem associated with high
mortality and high morbidity rates worldwide. Presently, its complex pathophysiology is still …

Perspectives in liver redox imbalance: toxicological and pharmacological aspects underlying iron overloading, nonalcoholic fatty liver disease, and thyroid hormone …

LA Videla, R Valenzuela - Biofactors, 2022 - Wiley Online Library
Oxidative stress is an imbalance between oxidants and antioxidants in favor of the oxidants,
leading to a disruption of redox signaling and control, and/or molecular damage altering …

Lipotoxicity in the heart

AR Wende, ED Abel - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2010 - Elsevier
Obesity and insulin resistance are associated with ectopic lipid deposition in multiple
tissues, including the heart. Excess lipid may be stored as triglycerides, but are also shunted …

[HTML][HTML] Metabolic liver disease of obesity and role of adipose tissue in the pathogenesis of nonalcoholic fatty liver disease

K Qureshi, GA Abrams - World journal of gastroenterology: WJG, 2007 - ncbi.nlm.nih.gov
Nonalcoholic fatty liver disease (NAFLD) is an increasingly recognized cause of liver-related
morbidity and mortality. It can develop secondary to numerous causes but a great majority of …

The role of fatty acids in the development and progression of nonalcoholic fatty liver disease

CL Gentile, MJ Pagliassotti - The Journal of nutritional biochemistry, 2008 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) has emerged as a serious obesity-related disorder.
NAFLD encompasses a wide spectrum of hepatic derangements ranging from a surfeit of fat …

[HTML][HTML] Omega-3 fatty acids for the treatment of non-alcoholic fatty liver disease

MND Di Minno, A Russolillo, R Lupoli… - World journal of …, 2012 - ncbi.nlm.nih.gov
Non-alcoholic fatty liver disease (NAFLD) has been recognized as a major health burden. It
is the most important cause of chronic liver disease and a major independent cardiovascular …

Oxidative stress and pro-inflammatory status in patients with non-alcoholic fatty liver disease

M Monserrat-Mesquida, M Quetglas-Llabrés, M Abbate… - Antioxidants, 2020 - mdpi.com
Background: Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive fat
accumulation, especially triglycerides, in hepatocytes. If the pathology is not properly …

The importance of the long-chain polyunsaturated fatty acid n-6/n-3 ratio in development of non-alcoholic fatty liver associated with obesity

R Valenzuela, LA Videla - Food & function, 2011 - pubs.rsc.org
Non-alcoholic fatty liver disease (NAFLD) is the most important cause of chronic liver
disease that is characterized by hepatocyte triacylglycerol accumulation (steatosis), which …

Impact of oxidized low density lipoprotein on vascular cells

J Galle, T Hansen-Hagge, C Wanner, S Seibold - Atherosclerosis, 2006 - Elsevier
Oxidized LDL (OxLDL) is a proatherogenic lipoprotein, accumulating in the vascular wall
and contributing to the pathogenesis of vascular dysfunction early in the development of …