IN THE LATE 1980s and early 1990s, the elucidation of the molecular basis of acute
promyelocytic leukemia (APL) emerged as a paradigm for the connection between the …

The PML gene, involved in the t (15; 17) chromosomal translocation of acute promyelocytic
leukemia (APL), encodes a protein which localizes to the PML-nuclear body, a subnuclear …

The PML protein is associated to nuclear bodies (NBs) whose functions are as yet unknown.
PML and two other NBs-associated proteins, Sp100 And ISG20 are directly induced by …

Cell death is generally classified into two large categories: apoptosis represents active,
programmed cell death, while necrosis represents passive cell death without underlying …

PML fuses with retinoic acid receptor α (RARα) in the t (15; 17) translocation that causes
acute promyelocytic leukemia (APL). In addition to localizing diffusely throughout the …

ABSTRACT PML is a nuclear phosphoprotein that was first identified as part of a
translocated chromosomal fusion product associated with acute promyelocytic leukaemia …

In acute promyelocytic leukemia (APL) patients, retinoic acid (RA) triggers differentiation
while arsenic trioxide (arsenic) induces both a partial differentiation and apoptosis. Although …

It has become clear that the nucleus is organized into discrete structures. Although not
membrane bound, these structures are considered nuclear organelles. Widespread interest …

The promyelocytic leukaemia (PML) gene is translocated in most acute promyelocytic
leukaemias and encodes a tumour suppressor protein. PML is involved in multiple apoptotic …

Retinoids are essential for the maintenance of epithelial differentiation. As such, they play a
fundamental role in chemoprevention of epithelial carcinogenesis and in differentiation …