Each cell is under constant surveillance to maintain the integrity of its genome. Genomic
lesions in a cell must be repaired before the onset of DNA replication and cell division. In the …

IGHTY-FIVE PERCENT of follicular lymphomas and E 20% of diffuse B-cell lymphomas have
a characteristic t (14; 18) translocation.'.'In this translocation, the proto-oncogene BCL2 at …

Aberrant inhibition of programmed cell death (apoptosis) prevents normal homeostasis and
promotes tissue tumorigenesis, but whether it also influences the outcome of common …

Defects in apoptosis signaling pathways are common in cancer cells. Such defects may play
an important role in tumor initiation because apoptosis normally eliminates cells with …

Expression and function of the TRAIL apoptotic pathway was investigated in normal and
malignant breast epithelial cells. Glutathione-S-transferase (GST)-TRAIL extracellular …

Bcl-2 gene product functions to prevent apoptosis in a variety of in vitro and in vivo
experiments. The prognostic significance of Bcl-2 protein expression was investigated by …

BACKGROUND Women with metastatic breast carcinoma have a highly variable clinical
course and outcome. Intrinsic genetic heterogeneity of the primary breast tumor may play a …

We have found that 17β-estradiol induces bcl-2 transcription in human breast cancer MCF-7
cells. To identify cis-acting elements involved in this regulation, we have analyzed hormone …

Survivin is a member of the inhibitor of apoptosis (IAP) family, and is also involved in the
regulation of cell division. Survivin is widely expressed in foetal tissues and in human …

Although metastatic breast cancer is responsive to radioimmunotherapy (RIT), a
systemictargeted radiation modality, complete and permanent remissions are not typical with …